The effect of vanadium compounds on carbohydrate and lipid metabolism disorders

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Abstract


At this stage in the development of nutriciological science, it has not been established if biologically active substances are essential to the human body; however, an explanation of the physiological role of minor biologically active substances is necessary to clarify the qualitative composition of Nutrioma. Of particular interest is the transition metal, vanadium. Adding vanadium to the diet of animals with induced or genetically determined type 2 diabetes mellitus normalizes glucose and blood insulin levels, reduces insulin resistance, promotes β-cell regeneration, and has a beneficial effect on lipid metabolism. Clinical studies of the effectiveness of vanadium are not convincing, in most part, because of their insufficient duration. The review briefly discusses the main mechanisms of the action of vanadium compounds. Therapeutic doses of vanadium compounds may overlap with toxic doses. Organic vanadium compounds could be used in significantly lower doses. The main problem with the possible use of vanadium compounds in antidiabetic therapy is the balance between their beneficial effects and the connected risks of side effects.


Yuliya S. Sidorova

Federal Research Centre of Nutrition, Biotechnology and Food Safety

Author for correspondence.
Email: sidorovaulia28@mail.ru
ORCID iD: 0000-0002-2168-2659
SPIN-code: 1978-7905
Scopus Author ID: 55452269800

Russian Federation, 109240, Moscow, Ustyinsky proezd, 2/14

PhD

Margarita G. Skalnaya

RUDN University

Email: skalnaya@yandex.ru
ORCID iD: 0000-0003-1099-2560
SPIN-code: 7079-4874

Russian Federation, 6, Miklukho-Maklaya street, Moscow, 117198

MD, PhD, professor

Aleksey A. Tinkov

RUDN University; P.G. Demidov State University of Yaroslavl

Email: tinkov.a.a@gmail.com
ORCID iD: 0000-0003-0348-6192
SPIN-code: 3329-3442

Russian Federation, 6, Miklukho-Maklaya street, Moscow, 117198; 14, Sovetskaya street,Yaroslavl, 150003

MD, PhD

Vladimir K. Mazo

Federal Research Centre of Nutrition, Biotechnology and Food Safety

Email: mazo@ion.ru
ORCID iD: 0000-0002-3237-7967
SPIN-code: 4142-4720

Russian Federation, 109240, Moscow, Ustyinsky proezd, 2/14

PhD, professor

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