Primary hyperparathyroidism in Russia according to the registry

  • Authors: Mokrysheva N.1, Dobreva E.1, Maganeva I.1, Mirnaya S.1, Kovaleva E.1, Krupinova J.1, Tevosyan L.2, Kryukova I.2, Lukyanov S.3, Markina N.4, Bondar I.5, Podprugina N.6, Shabelnikova O.5, Ignatieva I.6, Dreval A.2, Antsiferov M.2, Melnichenko G.1, Dedov I.1
  • Affiliations:
    1. Endocrinology Research Centre
    2. M.F. Vladimirskiy Moscow Regional Research and Clinical Institute
    3. Rostov state medical university, Russia, Rostov-on-Don
    4. Endocrinological Dispensary of the Moscow Healthcare Department, Russia, Moscow
    5. Novosibirsk State Medical University
    6. Nizhny Novgorod City hospital №33
  • URL: https://probl-endojournals.ru/probl/article/view/10126
  • DOI: https://doi.org/10.14341/probl10126
Open Access Open Access
Restricted Access Subscription Access

Abstract


Aim: to assess the detectability of primary hyperparathyroidism and its form characteristic in Russia using an online registry.

Methods: the database of patients with PHPT, which started in the Endocrinology Research Centre in 2007 and transferred onto online platform in 2016.

Results: the total number of patients with PHPT in the registry on 31 of December, 2017 was 1914 (0.001% of the population of the Russian Federation). Identification of PHPT per 100 thousand of the adult population in Moscow was 13 cases, in the Moscow region- 3.4 cases per 100 thousand. The active phase of the disease was registered in 84.6% of patients, most of whom had a manifest course of PHPT - 67.1%, and 32.9% - a mild course.  The mixed form of the disease was detected in 35.8% of patients with manifest form; isolated bone form in 48.4%, isolated visceral in 15.8%. Normocalcemic variant PHPT (nPHPT) was registered in 14.5% cases. Sporadic PHPT occurs in 83% of cases. 326 patients (17%) had a suspicion of hereditary form of the disease. A genetic analysis was conducted in 61 people (3.2%): showed the mutation MEN1 in 2.9% of cases and the mutation in the CDC73 gene – in 0.3% of cases (HPT -JT syndrome). Parathyroid carcinoma was confirmed in 1.8% of all patients. Surgical treatment was performed in 64.5% of patients.  Remission was achieved in 94% of cases. In 6% of cases relapse after surgical treatment was recorded.

Conclusion: detection of PHPT in the Russian Federation more than doubled in comparison to 2016, which is associated with an active start of registration of patients in the regions. At this stage it is necessary to modify the registration principles, which will make it possible to set up an online system for obtaining information to calculate the necessary volumes of medical care for PHPT patients.


Natalia Mokrysheva

Endocrinology Research Centre

Email: nm70@mail.ru
ORCID iD: 0000-0002-9717-9742
SPIN-code: 5624-3875
11 Dm. Ulyanova street, 117036 Moscow, Russia

MD, PhD

Ekaterina Dobreva

Endocrinology Research Centre

Email: dobrevae@mail.ru
ORCID iD: 0000-0002-8916-7346
SPIN-code: 3405-2467
11 Dm. Ulyanova street, 117036 Moscow, Russia

MD

Irina Maganeva

Endocrinology Research Centre

Author for correspondence.
Email: maganeva.ira@yandex.ru
ORCID iD: 0000-0002-0067-3622
SPIN-code: 2575-3091

Russian Federation, 11 Dm. Ulyanova street, 117036 Moscow, Russia

MD

Svetlana Mirnaya

Endocrinology Research Centre

Email: svetlanamirnaya@yahoo.com
ORCID iD: 0000-0002-1341-0397
SPIN-code: 1968-7706
11 Dm. Ulyanova street, 117036 Moscow, Russia

MD

Elena Kovaleva

Endocrinology Research Centre

Email: hypopara.enc@gmail.com
ORCID iD: 0000-0002-9258-2591
SPIN-code: 7387-6791
11 Dm. Ulyanova street, 117036 Moscow, Russia

MD

Julia Krupinova

Endocrinology Research Centre

Email: j.krupinova@gmail.com
ORCID iD: 0000-0001-7963-5022
SPIN-code: 6279-8247
11 Dm. Ulyanova street, 117036 Moscow, Russia

MD

Larisa Tevosyan

M.F. Vladimirskiy Moscow Regional Research and Clinical Institute

Email: tlh_moscou@mail.ru
ORCID iD: 0000-0002-8954-1633
SPIN-code: 7376-4180
129110, г. Москва, ул. Щепкина 61/2, к.1

MD

Irina Kryukova

M.F. Vladimirskiy Moscow Regional Research and Clinical Institute

Email: kiv200877@yandex.ru
ORCID iD: 0000-0002-7876-5105
SPIN-code: 7669-3010
129110, г. Москва, ул. Щепкина 61/2, к.1

MD

Stanislav Lukyanov

Rostov state medical university, Russia, Rostov-on-Don

Email: svluk@rambler.ru
ORCID iD: 0000-0002-3317-0108
SPIN-code: 4181-8431
344022, Ростовская область, г. Ростов-на-Дону, переулок Нахичеванский, 29

MD, docent

Natalia Markina

Endocrinological Dispensary of the Moscow Healthcare Department, Russia, Moscow

Email: skovran4@gmail.com
ORCID iD: 0000-0003-2784-1726
119034, город Москва, улица Пречистенка, 37

MD, PhD

Irina Bondar

Novosibirsk State Medical University

Email: bondaria@oblmed.nsk.ru
ORCID iD: 0000-0003-4324-2926
SPIN-code: 6633-8947
630087, Сибирский федеральный округ, Новосибирская обл., г. Новосибирск, ул. Немировича-Данченко, 130

MD, PhD, Professor

Natalia Podprugina

Nizhny Novgorod City hospital №33

Email: natalia.gec15@mail.ru
ORCID iD: 0000-0003-1538-7335
SPIN-code: 1699-0753
603076, Нижегородская обл., г. Нижний Новгород, пр. Ленина, 54

MD, PhD

Olesia Shabelnikova

Novosibirsk State Medical University

Email: shabelnikova@oblmed.nsk.ru
ORCID iD: 0000-0003-3906-4784
SPIN-code: 5941-4815
630087, Сибирский федеральный округ, Новосибирская обл., г. Новосибирск, ул. Немировича-Данченко, 130

MD, PhD

Irina Ignatieva

Nizhny Novgorod City hospital №33

Email: ir.ignatieva-1@yandex.ru
ORCID iD: 0000-0002-2394-240X
SPIN-code: 6187-0270
603076, Нижегородская обл., г. Нижний Новгород, пр. Ленина, 54

MD

Alexander Dreval

M.F. Vladimirskiy Moscow Regional Research and Clinical Institute

Email: dreval@diabet.ru
ORCID iD: 0000-0002-3135-9003
SPIN-code: 5853-3989
129110, г. Москва, ул. Щепкина 61/2, к.1

MD, PhD, Professor

Mikhail Antsiferov

M.F. Vladimirskiy Moscow Regional Research and Clinical Institute

Email: antsiferov@rambler.ru
ORCID iD: 0000-0002-9944-2997
SPIN-code: 1035-4773
129110, г. Москва, ул. Щепкина 61/2, к.1

MD, PhD, Professor

Galina Melnichenko

Endocrinology Research Centre

Email: teofrast2000@mail.ru
ORCID iD: 0000-0002-5634-7877
SPIN-code: 8615-0038
117036, г. Москва, ул. Дмитрия Ульянова, д. 11

MD, PhD, Professor

Ivan Dedov

Endocrinology Research Centre

Email: dedov@endocrincentr.ru
ORCID iD: 0000-0002-8175-7886
SPIN-code: 5873-2280
117036, г. Москва, ул. Дмитрия Ульянова, д. 11

MD, PhD, Professor

  • Мокрышева Н.Г. Первичный гиперпаратиреоз: современное представление о проблеме. Лечение и профилактика; 2013, № 2 (6).
  • Кузнецов Н.С., Рожинская Л.Я., Лысенко М.А., Сморщок В.Н., Мокрышева Н.Г., Гуляева С.С. Тяжелое течение гиперпаратиреоза у пожилых. Клинические наблюдения. Проблемы эндокринологии; 2009; 1:3-36.
  • Castellano E., Tassone F., Attanasio R., Gianotti L., Pellegrino M., Borretta G. Mild primary hyperparathyroidism as defined in the Italian Society of Endocrinology’s Consensus Statement: prevalence and clinical features. Italian Society of Endocrinology (SIE, 2015). Journal of Endocrinological Investigation. March 2016, Volume 39, Issue 3, pp 349–354.
  • Bollerslev J, Marcocci C, Sosa M, Nordenstrom J, Bouillon R, Mosekilde L. Current evidence for recommendation of surgery, medical treatment and vitamin D repletion in mild primary hyperparathyroidism. Eur J Endocrinol; 2011; 165:851–864
  • Silverberg SJ, Bilezikian JP (1996). Evaluation and management of primary hyperparathyroidism. J Clin Endocrinol Metab 8:2036–2040
  • David А. Allerheiligen, Joe Schoeber, Robert E. Houston, Virginia K. Mohl and Karen M. Wildman. Hyperparathyroidism. Am Fam Physician. University of Wyoming, Casper, Wyoming. 1998 Apr 15;57(8):1795-1802.
  • Potts JT et al. Diagnosis and Management of Asymptomatic Primary Hyperparathyroidism. National Institutes of Health Consensus Development Conference Statement. October 29-31, 1990; 8(7):1-18.
  • Bilezikian JP, Potts JT. Asymptomatic primary hyper-parathyroidism: new issues and new questions—bridging the past with the future. J Bone Miner Res. 2002;17(Suppl2):N57-N67.
  • Eastell R, Arnold A, Brandi ML, Brown EM, D’Amour P, Hanley DA, et al. Diagnosis of asymptomatic primary hyperparathyroidism: proceedings of the third international workshop. J Clin Endocrinol Metab. 2009;94(2):340–50.
  • Bilezikian J.P., Brandi M.L., Eastell R. et al. Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the Fourth International Workshop // JCEM. 2014; 99: 3561–3569.
  • The Mattson Jack Group. Epidemiology of primary hyperparathyroidism in Europe – report commissioned by Amgen. 2003.
  • Yu N., Donnan P.T., Murphy M.J. et al. Epidemiology of primary hyperparathyroidism in Tayside, Scotland, UK // J. Clin. Endocrinol. 2009; 71: 485–493.
  • Мамедова Е.О., Мокрышева Н.Г., Рожинская Л.Я. Особенности первичного гиперпаратиреоза у пациентов молодого возраста. // Проблемы эндокринологии. 2018. Т. 64. № 3. С.163-169. doi: 10.14341/probl9399.
  • Silverberg S.J. Vitamin D deficiency and primary hyperparathyroidism // J. Bone Miner. Res. 2007; 22 (Suppl. 2): V100–V104.
  • Silverberg S.J., Clarke B.L., Peacock M. et al. Current issues in the presentation of asymptomatic primary hyperparathyroidism: proceedings of the Fourth International Workshop // JCEM. 2014; 99 (10): 3580–3594.
  • Мокрышева Н.Г., Еремкина А.К., Пигарова Е.А., Мирная С.С., Воронкова И.А., Крупинова Ю.А., Кузнецов Н.С., Рожинская Л.Я., Мельниченко Г.А., Дедов И.И. Клинические рекомендации. Первичный гиперпаратиреоз (ПГПТ): клиника, диагностика, дифференциальная диагностика, методы лечения. Пособие для врачей ООО «УП ПРИНТ», Москва, 2017
  • Дедов И.И., Рожинская Л.Я., Васильева Т.О., Мокрышева Н.Г. Эпидемиология первичного гиперпаратиреоза. Проблемы эндокринологии. 2010. Т. 56. № 5. С. 3-7.
  • De Geronimo S., Romagnoli E., Diacinti D.et al. The risk of fractures in postmenopausal women with primary hyperparathyroidism. Eur J Endocrinol 2006;155:3:415—420.
  • Castellano E, Attanasio R, Boriano A, Pellegrino M, Garino F, Gianotti L, Borretta G. Sex Difference in the Clinical Presentation of Primary Hyperparathyroidism: Influence of Menopausal Status. J Clin Endocrinol Metab. 2017 Nov 1;102(11):4148-4152. doi: 10.1210/jc.2017-01080.
  • Yeh M.W., Ituarte P.H.G., Zhou H.C. et al. Incidence and prevalence of primary hyperparathyroidism in a racially mixed population // JCEM. 2013; 98 (3): 1122–1129
  • Мокрышева Н.Г., Первичный гиперпаратиреоз. Эпидемиология, клиника, современные принципы диагностики и лечения. Автореферат. Москва 2011.
  • The american association of clinical endocrinologists and the american association of endocrine surgeons position statement on the diagnosis and management of primary hyperparathyroidism. Endocrine practice. Vol 11 No. 1 January/February 2005
  • Eller-Vainicher C., Chiodini I., Battista C. et al. Sporadic and MEN1-related primary hyperparathyroidism: differences in clinical expression and severity. J Bone Miner Res 2009;24:8:1404-1410.
  • Pardi E, Borsari S, Saponaro F, Bogazzi F, Urbani C, Mariotti S, Pigliaru F, Satta C, Pani F, Materazzi G, Miccoli P, Grantaliano L, Marcocci C, Cetani F. Mutational and large deletion study of genes implicated in hereditary forms of primary hyperparathyroidism and correlation with clinical features. PLoS One. 2017 Oct 16;12(10):e0186485. doi: 10.1371/journal.pone.0186485.
  • Leeuwaarde RS et.al. The future: medical advances in MEN1 therapeutic approaches and management strategies. Endocr Relat Cancer. 2017 Oct;24(10): T179-T193.
  • Busaidy N., Jimenez C., Habra M., Schultz P., El-Naggar A., Clayman G., Asper J., Diaz E., Evans D. Parathyroid carcinoma: A 22-year experience. Head Neck. 2004; 26(8): 716-726. doi: 10.1002/hed.20049.
  • Мокрышева Н.Г., Липатенкова А.К., Крупинова Ю.А. Рак околощитовидных желез: этиология, патогенез, клиническая картина, диагностика, лечение. Вестник ФГБУ" РОНЦ им. Н.Н. Блохина", т. 27, № 3-2016.
  • Мокрышева Н.Г., Перетокина Е.В., Рожинская Л.Я. Клинический пример консервативного ведения пациентки с манифестной формой первичного гиперпаратериоза. Терапевтический архив. 2014. Т. 86. № 8. С. 99-101.

Views

Abstract - 135

PDF (Russian) - 16

PlumX

Dimensions


Copyright (c) Mokrysheva N., Dobreva E., Maganeva I., Mirnaya S., Kovaleva E., Krupinova J., Tevosyan L., Kryukova I., Lukyanov S., Markina N., Bondar I., Podprugina N., Shabelnikova O., Ignatieva I., Dreval A., Antsiferov M., Melnichenko G., Dedov I.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies