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Resolution on the results of the first working meeting of the Scientific Advisory Board «Actual problems of glycemic variability as a new criterion of glycemic control and safety of diabetes therapy»

Cover Page
  • Authors: Antsiferov M.B.1, Galstyan G.R.2, Zilov A.V.3, Mayorov A.Y.2, Markova T.N.4,5, Demidov N.A.6, Koteshkova O.M.1, Laptev D.N.2, Vitebskaya A.V.3, Alekseeva Y.G.7, Stavtseva S.I.7
  • Affiliations:
    1. Moscow Health Care Department, Endocrinology Dispanserium
    2. Endocrinology Research Centre
    3. I.M. Sechenov First Moscow State Medical University (Sechenov University)
    4. City Clinical Hospital №52
    5. «A.I. Yevdokimov Moscow State University of Medicine and Dentistry» of the Ministry of Healthcare of the Russian Federation
    6. City Hospital of Troitsky and Novomoskovsky Administrative District
    7. Novo Nordisk
  • Issue: Vol 65, No 3 (2019)
  • Pages: 204-211
  • Section: Clinical guidelines
  • URL: https://probl-endojournals.ru/probl/article/view/10197
  • DOI: https://doi.org/10.14341/probl10197
  • Cite item
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Abstract


June 19, 2018 the meeting of the Scientific Advisory Board took place in Moscow, chaired by Professor G.R. Galstyan, (co-chair – A.V. Zilov) devoted to the discussion of the possibilities of improving the results of treatment of diabetes mellitus (DM) by consideration of «variability of glycemia» (VG) as an additional criterion of the glycemic control effectiveness (especially of insulin therapy) as well as one of the goals of treatment in patients with unstable glycemia.

The purpose of the working meeting was to develop a strategy for the introduction of VG as a predictor and an additional criterion in assessing the effectiveness and safety of hypoglycemic therapy to improve the pharmacotherapy of diabetes and reduce cardiovascular and total mortality.

Aims:

– to conduct a comprehensive data analysis of the relationship between VG and adverse DM outcomes, such as hypoglycemia, micro-and macrovascular complications, cardiovascular and total mortality;

– to accumulate and analyze published data and the experience of decrease of VG and improving outcomes of diabetes on the background of different versions of insulin therapy;

– to compare existing methods of glycaemia monitoring and VG assessment, their validity and availability in real practice in the context of limited budget;

– to analyze the informativeness, clinical and prognostic significance of various parameters of VG assessment and determine their reasonable «minimum» for a comprehensive assessment of VG as a criterion for evaluating the effectiveness of treatment of DM and predictors of negative diabetes outcomes.

The following reports were heard during the discussion:

Glycemic variability: clinical and prognostic value. Types of glycemic variability. (Alexey V. Zilov, MD, PhD in Medicine, Assistant Professor).

Methods of assessment of variability of glycemia in clinical trials and routine practice (Tatiana N. Markova, MD, PhD in Medicine, Professor).

Current international and national recommendations on glycemic monitoring (Gagik R. Galstyan, MD, PhD in Medicine, Professor).

Peculiarities of glycemic variability and its evaluation among children and adolescents (Alisa V. Vitebskaya, MD, PhD in Medicine).


Mikhail B. Antsiferov

Moscow Health Care Department, Endocrinology Dispanserium

Author for correspondence.
Email: antsiferov@rambler.ru
ORCID iD: 0000-0002-9944-2997
SPIN-code: 1035-4773

Russian Federation, 37, Pretchistenka str., Moscow, 119034

MD, PhD, Professor

Gagik R. Galstyan

Endocrinology Research Centre

Email: galstyangagik964@gmail.com
ORCID iD: 0000-0001-6581-4521
SPIN-code: 9815-7509

Russian Federation, 11, Dm. Ulyanova street, Moscow, 117036

MD, PhD, Professor

Alexey V. Zilov

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: azilov@hotmail.com
ORCID iD: 0000-0003-3494-8011
SPIN-code: 8575-1247

Russian Federation, 8-2, Trubetskaya street, Moscow, 119992

MD, PhD, assistant professor

Aleksandr Y. Mayorov

Endocrinology Research Centre

Email: education@endocrincentr.ru
ORCID iD: 0000-0001-5825-3287

Russian Federation, 11, Dm. Ulyanova street, Moscow, 117036

MD, PhD

Tatiana N. Markova

City Clinical Hospital №52; «A.I. Yevdokimov Moscow State University of Medicine and Dentistry» of the Ministry of Healthcare of the Russian Federation

Email: markovatn18@yandex.ru
ORCID iD: 0000-0002-4882-8494
SPIN-code: 5914-2890

Russian Federation, 3, Pekhotnaya str., Moscow, 123182; 20/1, Delegatskaya street, Moscow, 127473

MD, PhD, Professor

Nikolay A. Demidov

City Hospital of Troitsky and Novomoskovsky Administrative District

Email: nicolay13@mail.ru
ORCID iD: 0000-0001-8289-0032
SPIN-code: 7715-4508

Russian Federation, Moscow

MD, PhD

Olga M. Koteshkova

Moscow Health Care Department, Endocrinology Dispanserium

Email: koala58@mail.ru
ORCID iD: 0000-0001-8428-4116

Russian Federation, 37, Pretchistenka str., Moscow, 119034

MD, PhD

Dmitry N. Laptev

Endocrinology Research Centre

Email: laptevdn@ya.ru
ORCID iD: 0000-0002-4316-8546
SPIN-code: 2419-4019

Russian Federation, 11, Dm. Ulyanova street, Moscow, 117036

MD, PhD

Alisa V. Vitebskaya

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: dr.vitebskaya@mail.ru
ORCID iD: 0000-0001-5689-0194
SPIN-code: 9857-9551

Russian Federation, 8-2, Trubetskaya street, Moscow, 119992

MD, PhD

Yana G. Alekseeva

Novo Nordisk

Email: alexeeva.jga@gmail.com
ORCID iD: 0000-0002-5014-9239
SPIN-code: 4954-0700

Russian Federation, 15 Bld. 5, Krylatskaya str, Krylatsky Hills Business Park,  Moscow, 121614 

MD, PhD

Svetlana I. Stavtseva

Novo Nordisk

Email: svpo@novonordisk.com
ORCID iD: 0000-0002-6705-9942

Russian Federation, 15 Bld. 5, Krylatskaya str, Krylatsky Hills Business Park,  Moscow, 121614 

Regional Medical Adviser, CMR dpt

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Supplementary files

Supplementary Files Action
1. Fig. 1. The relative effect of various indicators of glycemic variability on the overall risk of symptomatic and the risk of symptomatic nocturnal hypoglycemia (after 24 weeks of insulin therapy) (adapted from [23]). View (107KB) Indexing metadata
2. Fig. 2. The relationship between the high day-to-day variability of GPN and adverse outcomes (adapted from [13]). View (388KB) Indexing metadata

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Copyright (c) 2019 Antsiferov M.B., Galstyan G.R., Zilov A.V., Mayorov A.Y., Markova T.N., Demidov N.A., Koteshkova O.M., Laptev D.N., Vitebskaya A.V., Alekseeva Y.G., Stavtseva S.I.

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