Experimental assessment of diabetogenic effects of uric acid

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Abstract


The authors present the findings confirming the contribution of uric acid (UA) to the etiology and pathogenesis of diabetes mellitus. Experiments were carried out on 90 albino rats. It has been shown on the models of prediabetes and latent and mani- fest diabetes mellitus that hyperuricaemia (HU) is not only a sign, characterizing the severity of carbohydrate disorders, but a factor promoting the progress of these shifts as well. The diabetogenic effect of HU is the more significant, the more manifest are the background carbohydrate disorders. Preinjection of UA to animals markedly potentiated the diabetogenic effect of alloxane.


I. V. Madyanov

Regional Diabetes Center of the Ministry of Health of the Chuvash Republic

Author for correspondence.
Email: probl@endojournals.ru

Russian Federation, Cheboksary

M. I. Balabolkin

MMA n.a. I. M. Sechenova

Email: probl@endojournals.ru

Russian Federation, 2-8, Trubetskaya str., Moscow, 119992

A. A. Grigorev

Regional Diabetes Center of the Ministry of Health of the Chuvash Republic

Email: probl@endojournals.ru

Russian Federation, Cheboksary

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Copyright (c) 1997 Madyanov I.V., Balabolkin M.I., Grigorev A.A.

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