The content of bioactive and immunoreactive luteinizing hormone in the blood during injections of gonadotropin releasing factor to patients with pituitary adenoma

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Abstract


The secretion of bioactive (LHb) and immunoreactive (LHj) in response to gonadotropic hormone releasing factor (GHRF) was assessed in 8 women with pituitary macroadenoma (gonadotropinoma) and 6 patients with pituitary microadenoma combined with the polycystic ovaries syndrome. GHRF more intensively stimulated the secretion of LHb in patients with macroadenoma than that of LHj. If the level of estrogens in the blood increases, the secretion of LHb decreases in comparison with the production of LHi. In patients with pituitary microadenoma combined with the polycystic ovaries syndrome GHRF stimulated the secretion of LHj more intensively than that of LHb.


N. P. Goncharov

Endocrinology Research Center RAMS

Author for correspondence.
Email: probl@endojournals.ru

Russian Federation, Moscow

A. D. Dobracheva

Endocrinology Research Center RAMS

Email: probl@endojournals.ru

Russian Federation, Moscow

V. V. Vaks

Endocrinology Research Center RAMS

Email: probl@endojournals.ru

Russian Federation, Moscow

I. S. Yarovaya

Endocrinology Research Center RAMS

Email: probl@endojournals.ru

Russian Federation, Moscow

N. B. Akopova

Endocrinology Research Center RAMS

Email: probl@endojournals.ru

Russian Federation, Moscow

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Copyright (c) 1997 Goncharov N.P., Dobracheva A.D., Vaks V.V., Yarovaya I.S., Akopova N.B.

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