The experience of using biguanide siofor with polycystic ovary

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Abstract


The effect of the biguanide siofor (metformin) on the menstrual function of the endometrium and on hormonal and metabolic parameters was studied in 27 patients with ovarian polycystosis (OPC), of them 15 patients (mean age 30.7±1.7 years) were treated with the antidiabetic biguanide siofor (Berlin-Chemi) for 3 months. Siofor (metformin) used alone in patients with OPC was effective in restoring a regular menstrual cycle in 60% of cases and concurrently showed a moderate decrease in body weight. There was a significant reduction in the blood level of luteinizing hormone (LH) in most siofor-treated patients with OPC (more frequently in obese patients), which is indicative of that it is important to correct the states of central parts of the reproductive system, which are involved (along with insulin resistance and impaired steroidogenesis) in the development and formation of a clinical picture of the disease. The elevated concentration of C-peptide was found in the blood, which might be one of the manifestations of overcoming insulin resistance.


L. M. Bershtein

Petrov GUN Research Institute of Oncology, Ministry of Health of the Russian Federation

Author for correspondence.
Email: probl@endojournals.ru

Russian Federation

E. V. Tsyrlina

Petrov GUN Research Institute of Oncology, Ministry of Health of the Russian Federation

Email: probl@endojournals.ru

Russian Federation

I. E. Meshkova

Petrov GUN Research Institute of Oncology, Ministry of Health of the Russian Federation

Email: probl@endojournals.ru

Russian Federation

T. E. Poroshina

Petrov GUN Research Institute of Oncology, Ministry of Health of the Russian Federation

Email: probl@endojournals.ru

Russian Federation

V. I. Novik

Petrov GUN Research Institute of Oncology, Ministry of Health of the Russian Federation

Email: probl@endojournals.ru

Russian Federation

L. A. Krasil'nikova

Petrov GUN Research Institute of Oncology, Ministry of Health of the Russian Federation

Email: probl@endojournals.ru

Russian Federation

I. G. Kovalenko

Petrov GUN Research Institute of Oncology, Ministry of Health of the Russian Federation

Email: probl@endojournals.ru

Russian Federation

  1. Берштейн Л. М. Гормональный канцерогенез. — СПб,2000.
  2. Берштейн Л. М., Гамаюнова В. Б., Квачевская Ю. О. и др. // Вопр. онкол. — 2000. — Т. 46, № 2. — С. 191-195.
  3. Бохман Я. В. Руководство по гинекологической онкологии. — Л., 1989.
  4. Григорян О. Г., Анциферов М. Б. // Пробл. репрод. — 2000. - № 3. - С. 21-27.
  5. Дилъман В. М., Берштейн Л. М., Бобров Ю. Ф. и др. // Фи- зиол. человека. — 1981. — № 2. — С. 357-361.
  6. Манухин И. Б., Геворкян М. А., Кухаркина О. Б. // Акуш. и гин. - 2002. - № 2. - С. 18-21.
  7. Мишиева Н. Г., Назаренко Т. А., Фонченко Н. Д. // Акуш. и гин. - 2002. - № 2. - С. 18-25.
  8. Dunaif A., Segal К. R., Futterweit W., Dobrjansky А. // Diabetes. - 1989. - Vol.38. - Р. 1165-1174.
  9. Eagleson С. A., Gingrich М. В., Marshall J. С. et al. // J. Clin. Endocrinol. Metab. - 2000. - Vol. 85. - P. 4047-4052.
  10. Glueck C. J., Wang P., Fountaine R. et al. // Metabolism. — 1999. - Vol. 48. - P. 511-519.
  11. Ibanez L., Valls C., Potau N. et al. // J. Clin. Endocrinol. Metab. - 2000. - Vol. 85. - P. 3526-3530.
  12. Moghetti P., Castello R., Negri C. et al. // J. Clin. Endocrinol. Metab. - 2000. - Vol. 85. - P. 139-146.
  13. Morin-Papunen L. C., Vauhkonen I., Koivunen R. M. et al. // Hum. Reprod. - 2000. - Vol. 15. - P. 1266-1274.
  14. Nestler J. E., Jakubowicz D. J., Ewans W. S., Pasquali Л. // N. Engl. J. Med. - 1998. - Vol. 338. - P. 1876-1880.
  15. Poretsky L., Cataldo N. A., Rosenwaks Z., Giudice L. C. // En- docr. Rev. - 1999. - Vol. 20. - P. 535-582.
  16. Salha O., Martin-Hirsch P., Lane G., Sharma V. // Hum. Reprod. - 1997. - Vol. 12. - P. 959-962.
  17. Velazquez E., Acosta A., Mendoza S. G. // Obstet. and Gynecol. - 1997. - Vol. 90. - P. 392-395.
  18. Vrbikova J., Hill M., Starka L. et al. // Eur. J. Endocrinol. —2001- Vol. 144. - P. 69-628.

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Copyright (c) 2004 Bershtein L.M., Tsyrlina E.V., Meshkova I.E., Poroshina T.E., Novik V.I., Krasil'nikova L.A., Kovalenko I.G.

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