The informative value of the parameters of lymphocytic enzyme activity in patients with autoimmune thyroid diseases

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Abstract


The informative value of lymphocytic metabolic enzymes in female patients with diffuse toxic goiter (DTG) and autoimmune thyroiditis (AIT) was comparatively studied. The decreased activity of enzymes (mainly a mitochondrial compartment) determining the level of aerobic respiration is a common feature of the metabolism of peripheral lymphocytes in females with DTG and AIT. The lower activity of NA D-dependent dehydrogenases of the Krebs' cycle in the lymphocytes in females with aytoimmune thyroid disease leads to an increase in the significance of the levels of malic-enzyme and NADP-dependent glutamate dehydrogenase, which was revealed by a neuronet predictor. The specific feature of the metabolism of immunocompetent cells in patients with A IT was found to have enzymatic activity changes, suggesting a decrease in the substrate current by glycosis, which is accompanied by an increase in the value of an aerobic reaction of lactate dehydrogenase (LDH) in the neuronet model. On the contrary, patients with AIT were found to have changes in a number of cytoplasmatic dehydrogenases whose altered activity stimulated the rate of glycolysis and caused an increase in the anaerobic reaction of LDH.


A. A. Savchenko

Institute of Medical Problems of the North SB RAMS; Endocrinology Center at the Regional Clinical Hospital No. 1

Author for correspondence.
Email: probl@endojournals.ru

Russian Federation

S. G. Kadricheva

Institute of Medical Problems of the North SB RAMS; Endocrinology Center at the Regional Clinical Hospital No. 1

Email: probl@endojournals.ru

Russian Federation

S. A. Dogadin

Institute of Medical Problems of the North SB RAMS; Endocrinology Center at the Regional Clinical Hospital No. 1

Email: probl@endojournals.ru

Russian Federation

A. Yu. Burakov

Institute of Medical Problems of the North SB RAMS; Endocrinology Center at the Regional Clinical Hospital No. 1

Email: probl@endojournals.ru

Russian Federation

  1. Березов Т. Т, Коровкин Б. Ф. Биологическая химия. - М.,1998.
  2. Горбань А. Н., Россиев Д. А. Нейронные сети на персональном компьютере. - Новосибирск, 1996.
  3. Грязева Н. И., Робинсон М. В., Барыкина Н. Н. и др. // Бюл. экспер. биол. - 1998. - Т. 125, № 5. - С. 555-557.
  4. Дедов И. И., Мельниченко Г. А., Фадеев В. В. Эндокринология. Краткий справочник. - М., 1998.
  5. Савченко А. А., Сунцова Л. Н. // Лаб. дело. - 1989. - № И. - С. 23-25.
  6. Хаитов Р. М., Земсков А. М., Земсков В. М. // Иммунология. - 1996. - № 3. - С. 7-10.
  7. Aidoo A., Feuers R. J., Lyn-Cook L. Е. et al. // Cell. Biol. Toxicol. - 1996. - Vol. 12, N 2. - P. 79-87.
  8. Al-Ali A. K. /1 Ann. Clin. Biochem. - 1994. - Vol. 31, N 3.-P. 296-297.
  9. Boyum A. // Scand. J. Clin. Lab. Invest. - 1968. - Vol. 21.-Suppl. 97. - P. 77-80.
  10. Howlett R. A., Willis W. T. // Biochim. Biophys. Acta. - 1998. - Vol. 1363, N 3. - P. 224-230.
  11. Lowe G. M., Hulley С. E., Rhodes E. S. et al. // Biochem. Biophys. Res. Commun. - 1998. - Vol. 245, N 1. - P. 17-22.
  12. Malini T, Arunakaran J., Aruldhas M. M., Govindarajulu P. // Biochem. Mol. Biol. Int. - 1999. - Vol. 47, N 3. - P. 537- 545.
  13. Mirakian R., Hammond L. J., Botazzo G. F. // Imunol. Today. - 1998. - Vol. 19 - N 2. - P. 97-98.
  14. Velot C., Mixon M. B., Teige M., Srere P. A. // Biochemistry. -Vol. 36, N 47. - P. 14271-14276.
  15. Watanabe M., Amino N., Hochito K. et al. //Thyroid. - 1997.

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Copyright (c) 2003 Savchenko A.A., Kadricheva S.G., Dogadin S.A., Burakov A.Y.

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