Effects of second-generation sulfanilamides on the activity of ATP-dependent K+-channels of pancreatic β-cells

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Abstract


The activity of ATP-dependent K+-channels of intact pancreatic β-cells and functionally weak β-cells after streptosotocin treatment is analyzed and the reaction of these channels to sulfonyl drugs (glybenclamide, glypiside, and glyclaside) is evaluated. The ionic channels specifically reacted to glucose and sulfonyl drugs. Analysis of the time course of electrophysiological processes in the channels showed a shorter duration of a discharge and a longer interval between discharges, which decelerated insulin secretion starting from the moment of glucose or sulfonyl treatment till exotocytosis of insulin quantum. Glybenclamide was the most effective of the tested drugs as regards secretory activity under experimental conditions.


V. N. Babichev

Endocrinology Research Center of RAMS

Author for correspondence.
Email: probl@endojournals.ru

Russian Federation

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