Corticosteroid-binding globulin in experimental hypothyroidism in male and female rats

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Abstract


Main parameters of complex formation of corticosteroid-binding globulin (CSG) were studied in young male and female rats with hypothyrosis induced by mercasolyl in a daily dose of 6 and 30 mg/kg. No pronounced differences in CSG, typical of adult animals, were observed in young rats under conditions of thyroid function inhibition. Steroidand androgen-inhibitory and estrogen-inducing effects of hormones towards CSG did not manifest in hypothyrosis. Decrease in the level of thyroid hormones is characterized by increased affinity of CSG for glucocorticoids and a decrease in the concentration of binding sites. These data indicate that thyroid hormones are the primary regulators of CSG activity. Possibility of modifying CSG affinity and role of this factor in regulation of biological activity of glucocorticoids are discussed.


L. I. Nadolnik

Institute of Biochemistry of the National Academy of Sciences of the Republic of Belarus

Author for correspondence.
Email: probl@endojournals.ru

Belarus

N. V. Emelyanov

Institute of Biochemistry of the National Academy of Sciences of the Republic of Belarus

Email: probl@endojournals.ru

Belarus

I. P. Pasteur

Institute of Biochemistry of the National Academy of Sciences of the Republic of Belarus

Email: probl@endojournals.ru

Belarus

V. V. Vinogradov

Institute of Biochemistry of the National Academy of Sciences of the Republic of Belarus

Email: probl@endojournals.ru

Belarus

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