Assessment of autoantibodies against 21-hydroxylase in the diagnosis of primary autoimmune adrenal insufficiency

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Abstract

Abstract


Primary adrenal insufficiency  is manifested by a deficiency of adrenal cortex hormones and can lead to a life-threatening condition. Early diagnosis is key to patient survival. Auto-antibodies to one of the adrenal steroidogenesis enzymes, 21-hydroxylase, are an immunological marker of autoimmune adrenal insufficiency. On the one hand, the study of antibodies to 21-hydroxylase is a method that helps establish the etiology of the disease — the autoimmune genesis of adrenal gland damage. On the other hand, the determination of autoantibodies to 21-hydroxylase is the only prognostic factor of the risk of adrenal insufficiency, which makes it possible  to prevent the development of acute adrenal crisis.

 The article provides a brief literature review on autoantibodies to 21-hydroxylase and the pathogenesis of autoimmune adrenal insufficiency, and a series of clinical cases that illustrates the significant role of autoantibodies to 21-hydroxylase in diagnosis of adrenal insufficiency.


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About the authors

Leila Sozaeva

Endocrinology Research centre

Author for correspondence.
Email: leila.sozaeva@gmail.com
ORCID iD: 0000-0002-5650-1440
SPIN-code: 9983-5662
Scopus Author ID: 56730766000
ResearcherId: C-7231-2012

Russian Federation, г.Москва, Ул.Дмитрия Ульянова, 11

Старший научный сотрудник

Nadezhda Makazan

Endocrinology Research centre

Email: Nmakazan@ya.ru
ORCID iD: 0000-0003-3832-6367
SPIN-code: 7156-6517
Scopus Author ID: 57192199028
ResearcherId: B-8929-2019

Russian Federation, г.Москва, Ул.Дмитрия Ульянова, 11

Старший научный сотрудник

Larisa Nikankina

Endocrinology Research centre

Email: larisa.nikankina@yandex.ru
ORCID iD: 0000-0002-1120-8240
SPIN-code: 2794-0008
Scopus Author ID: 57190192821

Russian Federation, г.Москва, Ул.Дмитрия Ульянова, 11

заведующий клинико-диагностической лабораторией

Natalya Malysheva

Endocrinology Research centre

Email: natalya.m@list.ru
ORCID iD: 0000-0001-6630-227X
SPIN-code: 5793-2550
Scopus Author ID: 57197834989

Russian Federation, г.Москва, Ул.Дмитрия Ульянова, 11

ведущий научный сотрудник

Ekaterina Kuvaldina

Russian Children's Clinical Hospital, Moscow

Email: katja3164@mail.ru
ORCID iD: 0000-0001-5466-4644
SPIN-code: 3602-5578

Russian Federation, Москва, Ленинский проспект 117

врач- детский эндокринолог

Maria Kareva

Endocrinology Research centre

Email: i_marusya@mail.ru
ORCID iD: 0000-0003-1320-6561
SPIN-code: 5221-4235
Scopus Author ID: 57192249938

Russian Federation, г.Москва, Ул.Дмитрия Ульянова, 11

заведующая детским отделением опухолей эндокринной системы

Elizaveta Orlova

Endocrinology Research centre

Email: elizaveta.orlova@mail.ru
ORCID iD: 0000-0001-6196-5322
SPIN-code: 5221-4235
Scopus Author ID: 19836983300

Russian Federation, г.Москва, Ул.Дмитрия Ульянова, 11

Ведущий научный сотрудник

Valentina Peterkova

Endocrinology Research centre

Email: peterkovava@hotmail.com
ORCID iD: 0000-0002-5507-4627
SPIN-code: 4009-2463
Scopus Author ID: 6701824828
ResearcherId: B-1344-2017

Russian Federation, г.Москва, Ул.Дмитрия Ульянова, 11

научный руководитель Института детской эндокринологии

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Copyright (c) Sozaeva L., Makazan N., Nikankina L., Malysheva N., Kuvaldina E., Kareva M., Orlova E., Peterkova V.

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