Metabolic disorders in the adult patients presenting with congenital adrenal hyperpl

Cover Page


A total of 55 patients at the age from 18 to 60 years presenting with the classical forms of congenital adrenal hyperplasia (CAH) were available for the estimation of the body mass index (BMI), measurement of AP, glycemia in OGTT, insulin level, HOMA index, and lipid content in blood sera. BMI ≥ 25 kg/m2 was documented in 56% of the women and in 47% of the men with CAH. Arterial hypertension occurred in 10% and 14% of the women and men respectively, disturbances of carbohydrate metabolism were diagnosed in 17% of the women and 7% of the men, but men alone suffered diabetes mellitus. 35% and 47% of the women and men presented with insulin resistance respectively. Dyslipidemia concomitant with CAH occurred in 69% of the women and 50% of the men. Disturbances of carbohydrate metabolism and arterial hypertension were largely associated with the elevated BMI while dyslipidemia in the first place correlated with the degree of CAH compensation. It is concluded that the patients with CAH are subject to the high prevalence of metabolic disorders. Special attention should be given to the patients with an excessive body mass and those having episodes of iatrogenic hypercorticism in their medical histories. Such patients most frequently exhibit a combination of metabolic disorders that constitutes a risk factor of the development of cardiovascular complications.

A I Sazonova


E A Troshina

N V Molashenko

  1. White P.C., Speiser P.W. Congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Endocrinol Rev 2000; 21: 245-291.
  2. Stikkelbroeck N.M., Oyen W.J., van der Wilt G.J., Hermus A.R., Otten B.J. Normal bone mineral density and lean body mass, but increased fat mass, in young adult patients with congenital adrenal hyperplasia. J Clin Endocrinol Metabol 2003; 88: 1036-1042.
  3. Falhammar H., Filipsson H., Holmdahl G., Janson P., Nordenkskjöld A., Hagenfeldt K., Thorén M. Metabolic profile and body composition in adult women with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. J Clin Endocrinol Metabol 2007; 92: 110-116.
  4. Bachelot A., Plu-Bureau G., Thibaud E., Laborde K., Pinto G., Samara D., Nihoul-Fékété C., Kuttenn F., Polak M., Touraine P. Long-term outcome of patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Hormone Res 2007; 67: 268-276.
  5. Hagenfeldt K., Martin R.E., Ringertz H., Helleday J., Carlstrom K. Bone mass and body composition of adult women with congenital virilizing 21-hydroxylase deficiency after glucocorticoid treatment since infancy. Eur J Endocrinol 2000; 143: 667-671.
  6. Völkl T.M., Simm D., Beier C., Dorr H.G. Obesity among children and adolescents with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Pediatrics 2006; 117: 98-105.
  7. Sartorato P., Zulian E., Benedini S., Mariniello B., Schiavi F., Bilora F., Pozzan G., Greggio N., Pagnan A., Mantero F., Scaroni C. Cardiovascular risk factors and ultrasound evaluation of intima-media thickness at common carotids, carotid bulbs, and femoral and abdominal aorta arteries in patients with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency. J Clin Endocrinol Metabol 2007; 92: 1015-1018.
  8. Buffington C.K., Givens J.R., Kitabchi A.E. Opposing actions of dehydroepiandrosterone and testosterone on insulin sensitivity. In vivo and in vitro studies of hyperandrogenic females. Diabetes 1991; 40: 693-700.


Abstract - 606




Copyright (c) 2012 Sazonova A.I., Troshina E.A., Molashenko N.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies