The role of modern technologies in the management of azoospermia using microdissection TESE in the framework of the ECF-ICSI program. A literature review. Part I.

Cover Page

Abstract


The present review is focused on the modern methods for the treatment of male infertility related to obstructive and unobstructive azoospermia. The criteria and prognostic factors for obtaining spermatozoa by means of invasive manipulations on the testicles are considered. Special attention is given to the results of investigations into the state of the AZF-region of Y-chromosome and of the studies of patients presenting with Klinefelter's syndrome. The modern classification of testicular biopsies is presented that allows to discriminate between different forms of compromised spermatogenesis.

I I Vitiazeva

Email: vitiazeva@yandex.ru

S V Bogoliubov

I I Dedov

  1. Willott G.M. Frequency of azoospermia. Forensic Sci Int 1982; 20: 9-10.
  2. Jarow J.P., Espeland M.A., Lipshultz L.I. Evaluation of the azoospermic patients. J Urol 1989; 142: 62.
  3. Черных В.Б. Ген муковисцидоза и нарушение фертильности у мужчин. Андрол и генитал хир 2010; 4: 23-31.
  4. Palermo G.D., Joris K., Devroey P., Van Steirteghem A.C. Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte. Lancet 1992; 340: 17-18.
  5. Van Steirteghem A.C., Nagy Z., Joris H., Liu J., Staessen C., Smitz J., Wisanto A., Devroey P. Higher fertilization and implantation rates after intracytoplasmic sperm injection. Hum Reprod 1993; 8: 1061-1066.
  6. Temple-Smith P.D., Southwick G.J., Yates C.A., Trounson A.O., de Kretser D.M. Human pregnancy by in vitro fertilization (IVF) using sperm aspirated from the epididymis. J In Vitro Fert Embryo Transf 1985; 2: 119-122.
  7. Craft I., Benett V., Nicholson N. Fertilising ability of testicular spermatozoa (Letter). Lancet 1993; 342: 864.
  8. Schoysman R., Vanderzwalmen P., Nijs M., Segal L., Segal-Bertin G., Geerts I., Roosendaal E., Schoysman D. Pregnancy after fertilisation with human testicular spermatozoa. Lancet 1993; 342: 1237.
  9. Devroey P., Liu J., Nagy Z., Tournaye H., Silber S.J., Van Steirteghem A.C. Normal fertilization of human oocytes after testicular sperm extraction and intracytoplasmic sperm injection. Fertil Steril 1994; 62: 639-641.
  10. Devroey P., Liu J., Nagy Z., Goossens A., Tournaye H., Camus M., Van Steirteghem A., Silber S. Pregnancies after testicular sperm extraction and intracytoplasmic sperm injection in non-obstructive azoospermia. Hum Reprod 1995; 10: 6: 1457-1460.
  11. Tournaye H., Camus M., Goosens A., Nagy Z., Silber S., Van Steirteghem A.C., Devroey P. Recent concepts in the management of infertility because of non-obstructive azoospermia. Hum Reprod 1995; 10: Suppl 1: 115-119.
  12. Tournaye H., Camus M., Vandervorst M., Nagy Z., Joris H., Van Steirteghem A., Devroey P. Surgical sperm retrieval for intracytoplasmic sperm injection. Int J Androl 1997; 20: Suppl 3: 69-73.
  13. Tournaye H., Liu J., Nagy P.Z., Camus M., Goossens A., Silber S., Van Steirteghem A.C., Devroey P. Correlation between testicular histology and outcome after intracytoplasmic sperm injection using testicular spermatozoa. Hum Reprod 1996; 11: 127-132.
  14. Schlegel P.N., Su L.M. Physiological consequences of testicular sperm extraction. Hum Reprod 1997; 12: 1688-1692.
  15. Meniru G.I., Gorgy A., Podsiadly B.T., Craft I.L. Results of percutaneous epididymal sperm aspiration and intracytoplasmic sperm injection in two major groups of patients with obstructive azoospermia. Hum Reprod 1997; 12: 11: 2443-2446.
  16. Friedler S., Raziel A., Strassburger D., Soffer Y., Komarovsky D., Ron-El R. Testicular sperm retrieval by percutaneous fine needle sperm aspiration compared with testicular sperm extraction by open biopsy in men with non-obstructive azoospermia. Hum Reprod 1997; 12: 1488-1493.
  17. Rosenlund B., Kvist U., Ploen L., Lundh Rozell B., Sjoblom P., Hillensjo T. A comparison between open and percutaneous needle biopsies in men with azoospermia. Hum Reprod 1998; 13: 1266-1271.
  18. Hauser R., Botchan A., Amit A., Ben Yosef D., Gamzu R., Paz G., Lessing J.B., Yogev L., Yavtz H. Multiple testicular sampling in non-obstructive azoospermia-is it necessary? Hum Reprod 1998; 13: 3081-3085.
  19. Schlegel P.N. Testicular sperm extraction: microdissection improves sperm yield with minimal tissue excision. Hum Reprod 1999; 14: 131-135.
  20. Jarow J.P., Espeland M.A., Lipshultz L.I. Evaluation of the azoospermic patients. J Urol 1989; 142: 62.
  21. Matsumiya K., Namiki M., Takahara S., Kondoh N., Takada S., Kiyohara H., Okuyama A. Clinical study of azoospermia. Int J Androl 1994; 17: 3: 140-142.
  22. Palermo G.D., Schlegel P.N., Hariprashad J.J., Ergun B., Mielnik A., Zaninovic N., Veeck L.L., Rosenwaks Z. Fertilization and pregnancy outcome with intracytoplasmic sperm injection for azoospermic men. Hum Reprod 1999; 14: 741-748.
  23. Ezeh U.I., Moore H.D.M., Cooke I.D. A prospective study of multiple needle biopsies versus a single open biopsy for testicular sperm extraction in en with non-obstructive azoospermia. Hum Reprod 1998; 13: 2075-2080.
  24. Raman J.D., Schlegel P. Testicular sperm extraction with intracytoplasmic sperm injection is successful for the treatment of nonobstructive azoospermia associated with cryptorchidism. J Urol 2003; 170: 1287-1290.
  25. Silber S.J., Rodriguez-Rigau L.J. Quantitative analysis of testicle biopsy: determination of partial obstruction and prediction of sperm count after surgery for obstruction. Fertil Steril 1981; 36: 4: 480-485.
  26. Silber S.,Nagy Z., Devroey P., Tournaye H., Van Steirteghem A.C. Distribution of spermatogenesis in the testicles of azoospermic men: the presence or abscence of spermatids in the testes of men with germinal failure. Hum Reprod 1997; 12: 2422-2428.
  27. Silber S.J. Microsurgical TESE and the distribution of spermatogenesis in non-obstructive azoospermia. Hum Reprod 2000; 15: 11: 2278-2284.
  28. Silber S. What forms of male infertility are left to cure? Hum Reprod 1995; 10: 503.
  29. Gil-Salom M., Romero J., Minguez Y., Molero M.D., Remohi J., Pellicer A. Testicular sperm extraction and intracytoplasmic sperm injection: A chance of fertility in nonobstructive azoospermia. J Urol 1998; 160: 2063-2067.
  30. Tash J.A., Schlegel P.N. Histologic effects of testicular sperm extraction on the testicle in men with nonobstructive azoospermia. J Urology 2001; 57: 334-337.
  31. Schlegel P.N., Su L.M. Physiological consequences of testicular sperm extraction. Hum Reprod 1997; 12: 1688-1692.
  32. Van Peperstraten A., Proctor M.L., Johnson N.P., Philipson G. Techniques for surgical retrieval of sperm prior to ICSI for azoospermia. Cochrane Database Syst Rev 2006; 19: 3: CD002807.
  33. Foresta C., Garolla A., Betella A., Ferlin A., Rossato M., Candiani F. Doppler ultrasound of the testis in azoospermic subjects as a parameter of testicular function. Hum Reprod 1998; 13: 3090-3093.
  34. Har-Toov J., Eytan O., Hauser R., Yavetz H., Elad D., Jaffa A.J. A new power doppler ultrasound guiding technique for improved testicular sperm extraction. Fertil Steril 2004; 81: 430-434.
  35. Jezek D., Knuth U.A., Schulze W. Successful testicular sperm extraction (TESE) in spite of high serum follicle stimulating hormone and azoospermia: correlation between testicular morphology, TESE results, semen analysis and serum hormone values in 103 infertile men. Hum Reprod 1998; 13: 5: 1230-1234.
  36. Levin H.S. Testicular biopsy in the study of male infertility. Hum Pathol 1979; 10: 569-584.
  37. Tournaye H., Verheyen G., Nagy P., Ubaldi F., Goosens A., Silber S., Van Steirteghem A.C., Devroey P. Are there any predictive factors for successful testicular sperm recovery in azoospermic patients? Hum Reprod 1997; 12: 80-86.
  38. Krausz C., Quinatana-Murci L., Mcelreavey K. Prognostic value of Y deletion analysis: What is the clinical prognostic value of Y chromosome microdeletion analysis? Hum Reprod 2000; 15: 1431-1434.
  39. Tiepolo L., Zuffardi O. Localization of factors controlling spermatogenesis in the nonfluorescent portion of the human Y chromosome long arm. Hum Genet 1976; 34: 2: 119-124.
  40. Vogt P.H., Edelmann A., Kirsch S., Henegariu O. Hirschmann P., Kiesewetter F., Köhn F.M., Schill W.B., Farah S., Ramos C., Hartmann M., Hartschuh W., Meschede D., Behre H.M., Castel A., Nieschlag E., Weidner W., Gröne H.J., Jung A., Engel W., Haidl G. Human Y chromosome azoospermia factors (AZF) mapped to different subregions in Yq11. Hum Mol Genet 1996; 5: 7: 933-943.
  41. Черных В.Б. Микроделеционный анализ AZF-локуса в рамках комплексного клинико-генетического обследования мужчин с азооспермией и олигоспермией: Автореф. дис. ... канд. мед. наук. М 2002; 25.
  42. Fu L., Ding X., Shen M., Li C., Nie S., Quan Q. Screening and clinical phenotype analysis of microdeletions of azoospermia factor region on Y chromosome in 1011 infertile men. Hum Reprod 2012; 29: 2: 184-187.
  43. Brandell R.A., Mielnik A., Liotta D., Ye Z., Veeck L.L., Palermo G.D., Schlegel P.N. AZFb deletions predict the absence of spermatozoa with testicular sperm extraction: preliminary report of a prognostic genetic test. Hum Reprod 1998; 13: 2812-2815.
  44. Foresta C., Moro E., Ferlin A. Prognostic value of Y deletion analysis. The role of current methods. Hum Reprod 2001; 16: 8: 1543-1547.
  45. Sadeghi-Nejad H., Farrokhi F. Genetics of azoospermia: current knowledge, clinical implications, and future directions. Part II: Y chromosome microdeletions. J Urol 2007; 4: 4: 192-206.
  46. Navarro-Costa P., Gonçalves J., Plancha C.E. The AZFc region of the Y chromosome: at the crossroads between genetic diversity and male infertility. Hum Reprod Update 2010; 16: 5: 525-542.
  47. Hadjkacem-Loukil L., Ghorbel M., Bahloul A., Ayadi H., Ammar-Keskes L. Genetic association between AZF region polymorphism and Klinefelter syndrome. Reprod Biomed Online 2009; 19: 4: 547-551.
  48. Choe J.H., Kim J.W., Lee J.S., Seo J.T. Routine screening for classical azoospermia factor deletions of the Y chromosome in azoospermic patients with Klinefelter syndrome. Asian J Androl 2007; 9: 6: 815-820.
  49. Козлова С.И., Демикова Н.С., Семанова Е., Блинникова О.Е. В кн.: Наследственные синдромы и медико-генетическое консультирование. М 1996; 305.
  50. Herlihy A.S., Halliday J.L., Cock M.L., McLachlan R.I. The prevalence and diagnosis rates of Klinefelter syndrome: an Australian comparison. Med J Aust 2011; 194: 1: 24-28.
  51. Forti G., Corona G., Vignozzi L., Krausz C., Maggi M. Klinefelter's syndrome: a clinical and therapeutical update. Sex Dev 2010; 4: 4-5: 249-258.
  52. Abdelmoula N.B., Amouri A., Portnoi M.F., Saad A., Boudawara T., Mhiri M.N., Bahloul A., Rebai T. Cytogenetics and fluorescence in situ hybridization assessment of sex-chromosome mosaicism in Klinefelter's syndrome. Ann Genet 2004; 47: 2: 163-175.
  53. Андрология. Мужское здоровье и дисфункция репродуктивной системы. Под ред. Э. Нишлага, Г.М. Бере. М: МИА 2005; 185-187.
  54. Баранов В.С., Кузнецова Т.В. Цитогенетика эмбрионального развития человека. М: Издательство Н-Л 2007; 199.
  55. Джонс К. Наследственные синдромы по Дэвиду Смиту: атлас-справочник. Пер. с англ. А.Г. Азова, И.А. Ивановой, А.В. Мишарина и др. М: Изд-во Практика 2011; 70-72.
  56. Schiff J.D., Palermo G.D., Veeck L.L., Goldstein M., Rosenwaks Z., Schlegel P.N. Success of testicular sperm extraction [corrected] and intracytoplasmic sperm injection in men with Klinefelter syndrome. J Clin Endocrinol Metab 2005; 90: 11: 6263-6267.
  57. Poulakis V., Witzsch U., Diehl W., de Vries R., Becht E., Trotnow S. Birth of two infants with normal karyotype after intracytoplasmic injection of sperm obtained by testicular extraction from two men with nonmosaic Klinefelter's syndrome. Fertil Steril 2001; 76: 1060-1062.
  58. Friedler S., Raziel A., Strassburger D., Schachter M., Bern O., Ron-El R. Outcome of ICSI using fresh and cryopreserved-thawed testicular spermatozoa in patients with non-mosaic Klinefelter's syndrome. Hum Reprod 2001; 16: 2616-2620.
  59. Nodar F., De Vincentiis S., Olmedo S.B., Papier S., Urrutia F., Acosta A. Birth of twin males with normal karyotype after intracytoplasmic sperm injection with use of testicular spermatozoa for a nonmosaic patient with Klinefelter's syndrome. Fertil Steril 1999; 71: 1149-1152.
  60. Ramasamy R., Ricci J.A., Palermo G.D., Gosden L.V., Rosenwaks Z., Schlegel P.N. Successful fertility treatment for Klinefelter's syndrome. J Urol 2009; 182: 3: 1108-1113.
  61. Madgar I., Dor J., Weissenberg R., Raviv G., Menashe Y., Levron J. Prognostic value of the clinical and laboratory evaluation in patients with nonmosaic Klinefelter syndrome who are receiving assisted reproductive therapy. Fertil Steril 2002; 77: 6: 1167-1169.
  62. Maiburg M.C., Hoppenbrouwers A.C., van Stel H.F., Giltay J.C. Attitudes of Klinefelter men and their relatives towards TESE-ICSI. J Ass Reprod Genet 2011; 28: 9: 809-814.
  63. McLachlan R.I., Rajpert-De Meyts E., Hoei-Hansen C.E., de Kretser D.M., Skakkebaek N.E. Histological evaluation of the human testis-approaches to optimizing the clinical value of the assessment: mini review. Hum Reprod 2007; 22: 2-16.
  64. Tournaye H. Gamete source and manipulation. In: Current Practices and Controversies in Assisted Reproduction. Eds. E. Vayena, P.J. Rowe, P. David, P.D. Griffin. Oxford: University Press 2002.
  65. Schoor R.A., Elhanbly S., Niederberger C.S., Ross L.S. The role of testicular biopsy in the modern management of male infertility. J Urol 2002; 167: 197-200.

Views

Abstract - 576

Cited-By


PlumX

Dimensions


Copyright (c) 2012 Vitiazeva I.I., Bogoliubov S.V., Dedov I.I.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies