Differential and diagnostic, predictive and therapeutic value of test with clomifene in men with a Hypogonadizm

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Abstract


Aim.

In the real research test with an antiestrogen clomifene is offered for differential diagnostics of potential reversibility of a hypogonadism.

Material and methods.

After initial determination of levels of testosterone and LH, to 55 men with a hypogonadism clomifene citrate of 50 mg orally daily in the morning for 10 days was administrated. Levels of testosterone and LH repeatedly were defined on the 11th day.

Results.

The carried-out test with clomifene eliminated a hypogonadism at 85,5% of patients, thus the effect remained at 40%. The test was safe, at one of men of side effects it wasn’t noted. For patients with negative result of test (preservation of a hypogonadism) administration of preparations of testosterone was recommended. 

Conclusions

Test allows not only to differentiate reversibility of a hypogonadism, but also in some cases completely to eliminate it.


Roman Viktorovich Rozhivanov

Endocrinology Research Centre

Author for correspondence.
Email: rrozhivanov@mail.ru

Russian Federation MD, PhD, Senior research associate department of Andrology and Urology 

Dmitriy Gennad'evich Kurbatov

Endocrinology Research Centre

Email: kurbatov.d@mail.ru

Russian Federation MD, PhD, Professor, Head of department of Andrology and Urology 

Nataliya Sergeevna Kravtsova

Endocrinology Research Centre

Email: drnot@mail.ru

Russian Federation

PhD student department of Andrology and Urology

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Copyright (c) 2016 Rozhivanov R.V., Kurbatov D.G., Kravtsova N.S.

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