Stimulation of a spermatogenesis at men gonadotrophins and an antiestrogen at a pathospermia and infertility

Cover Page

Abstract


Aim — to investigate the methods of treatment, directed on increase in quantity of spermatozoa in an ejaculate.

Material and methods. In investigation was used: chorionic gonadotrophin, anti-estrogen, recombinant preparations FSH, and also their combinations.

Results. The worst efficiency (10%) was noted when using monotherapy by preparation HCG. Efficiency of monotherapy by a preparation of clomiphene was higher and made 20% concerning conception, and 63% concerning an oligoteratozoospermiya. Efficiency of the combined therapy of HCG in combination with recombinant FSH was 40% concerning conception, and 87% concerning an oligoteratozoospermiya.

Conclusion. At the same time the studied types of the stimulating therapy are effective, safe and don’t lead to development of side effects.


Nataliya S. Kravtsova

Endocrinology Research Centre

Email: drnot@mail.ru

Russian Federation MD, PhD-student

Roman V. Rozhivanov

Endocrinology Research Centre

Author for correspondence.
Email: rrozhivanov@mail.ru

Russian Federation MD, PhD

Dmitriy G. Kurbatov

Endocrinology Research Centre

Email: kurbatov.d@mail.ru

Russian Federation MD, PhD, Head of the Urology department, Clinical Endocrinology Institute

  1. Всемирная организация здравоохранения. Руководство по лабораторному исследованию эякулята человека и взаимодействия сперматозоидов с цервикальной слизью. 4-е изд. – М.; 2001. – 144 с. [Who. Rukovodstvo po laboratornomu issledovaniyu eyakulyata cheloveka i vzaimodeystviya spermatozoidov s tservikal’noy sliz’yu. 4th edition. Moscow; 2001. 144 p. (In Russ.)].
  2. Андрология. Мужское здоровье и дисфункция репродуктивной системы / Под ред. Э. Нишлага, Г.М. Бере. – М.; 2005. – 554 с. [Andrology. Man’s health and reproductive system dysfunction. Ed by E. Nishlag, G.M. Bere. Moscow; 2005. 554 p. (In Russ.)].
  3. Yang L, Zhang SX, Dong Q, et al. Application of hormonal treatment in hypogonadotropic hypogonadism: more than ten years experience. Int Urol Nephrol. 2012;44(2):393-399. doi: 10.1007/s11255-011-0065-0.
  4. Amirzargar MA, Eavangi M, Basiri A, et al. Comparison of recombinant human follicle stimulating hormone (RHFSH), human chorionic gonadotropin (HCG) and human menopausal gonadotropin (HMG) on semen parameters after varicocelectomy: a randomized clinical trial. Iran J Reprod Med. 2012;10(5):441-452. PMC4169682.
  5. Sinisi AA, Esposito D, Bellastella G, et al. Efficacy of recombinant human follicle stimulating hormone at low doses in inducing spermatogenesis and fertility in hypogonadotropic hypogonadism. J Endocrinol Invest. 2010;33(9):618-623. doi: 10.1007/bf03346659.
  6. Chua ME, Escusa KG, Luna S, et al. Revisiting oestrogen antagonists (clomiphene or tamoxifen) as medical empiric therapy for idiopathic male infertility: a meta-analysis. Andrology. 2013;1(5):749-757. doi: 10.1111/j.2047-2927.2013.00107.x. doi: 10.14341/probl201662237-41

Supplementary files

There are no supplementary files to display.

Views

Abstract - 917

PDF (Russian) - 900

Remote (Russian) - 176

Cited-By


PlumX

Dimensions


Copyright (c) 2016 Kravtsova N.S., Rozhivanov R.V., Kurbatov D.G.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies