Developing models to predict persistent disease after pituitary adenoma surgery

Cover Page
  • Authors: Sampedro-Nuñez M.A.1,2, Martin Garcia R.2, Martin Avila G.2, García Centeno R.3, Blanco Carrera C.4,5, Álvarez-Escola C.6,2, de Miguel P.7, Gutiérrez M.C.8, Ramos-Leví A.M.1,2, Marazuela M.1,2
  • Affiliations:
    1. Hospital Universitario La Princesa
    2. Universidad Autónoma de Madrid
    3. Hospital Universitario Gregorio Marañón
    4. Hospital Universitario Príncipe de Asturias
    5. Alcalá de Henares
    6. Hospital Universitario La Paz
    7. Hospital Universitario Clínico
    8. Hospital Universitario 12 de octubre
  • Issue: Vol 62, No 5 (2016)
  • Pages: 68-69
  • Section: Short Messages
  • URL: https://probl-endojournals.ru/probl/article/view/8109
  • DOI: https://doi.org/10.14341/probl201662568-69
  • Cite item

Abstract


Introduction. Pituitary adenomas are the most frequent intracranial tumors of the central nervous system. Except for prolactinomas, surgery is the treatment of choice.

Aim: to assess the percentage of patients with persistent disease after surgery and to identify independent predictors of persistent disease.

Material and methods. Ambispective multicenter observational study. Data were collected from The Molecular Registry of Pituitary Adenomas (REMAH). Univariate and multivariate analysis were performed in 128 patients with histologically confirmed adenomas who underwent transsphenoidal surgery between 2009 and 2015 in hospitals from Madrid, with at least one month of follow-up.

Results. During follow-up, persistent disease was observed in 50.8% of patients (radiological 30.7%, biochemical 2.4%, both 14.2%), especially in nonfunctioning tumors. Factors significantly associated with persistent disease in the univariate analysis were age, male gender, previous hypopituitarism, large tumor diameter and microscopic transsphenoidal surgery (p <0.05). Independent predictors of persistent disease in multivariate analysis were: patients over 76 years old, a greater tumor diameter, multiple hypopituitarism and microscopic transsphenoidal surgery (p <0.05).

Conclusion. Age, tumor size, previous hypopituitarism and the type of surgical technique were independent predictors of persistent disease. These factors could be useful for clinicians in the follow-up of patients to better establish monitoring and treatment algorithms.


Miguel Antonio Sampedro-Nuñez

Hospital Universitario La Princesa; Universidad Autónoma de Madrid

Author for correspondence.
Email: msampedr@gmail.com

Spain MD, Department of Endocrinology, Instituto de Investigación Princesa

Raquel Martin Garcia

Universidad Autónoma de Madrid

Email: ana_ramoslevi@hotmail.com

Spain Medical Student, School of Medicine

Guillermo Martin Avila

Universidad Autónoma de Madrid

Email: ana_ramoslevi@hotmail.com

Spain Medical Student, School of Medicine

Rogelio García Centeno

Hospital Universitario Gregorio Marañón

Email: ana_ramoslevi@hotmail.com

Spain MD, PhD, Department of Endocrinology

Concepción Blanco Carrera

Hospital Universitario Príncipe de Asturias; Alcalá de Henares

Email: ana_ramoslevi@hotmail.com

Spain MD, PhD, Department of Endocrinology

Cristina Álvarez-Escola

Hospital Universitario La Paz; Universidad Autónoma de Madrid

Email: ana_ramoslevi@hotmail.com

Spain MD, PhD, Department of Endocrinology

Paz de Miguel

Hospital Universitario Clínico

Email: ana_ramoslevi@hotmail.com

Spain

María Calatayud Gutiérrez

Hospital Universitario 12 de octubre

Email: ana_ramoslevi@hotmail.com

Spain MD, consultant endocrinologist, Department of Endocrinology, Instituto de Investigación Princesa

Ana Maria Ramos-Leví

Hospital Universitario La Princesa; Universidad Autónoma de Madrid

Email: ana_ramoslevi@hotmail.com

Spain MD, PhD, Department of Endocrinology, Instituto de Investigación Princesa

Monica Marazuela

Hospital Universitario La Princesa; Universidad Autónoma de Madrid

Email: ana_ramoslevi@hotmail.com

Spain MD, PhD, Department of Endocrinology, Instituto de Investigación Princesa

Views

Abstract - 654

PDF (English) - 199

Cited-By


PlumX

Dimensions


Copyright (c) 2016 Sampedro-Nuñez M.A., Martin Garcia R., Martin Avila G., García Centeno R., Blanco Carrera C., Álvarez-Escola C., de Miguel P., Gutiérrez M.C., Ramos-Leví A.M., Marazuela M.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies