Association of adiponectin gene alleles with type 2 diabetes mellitus in residents of Bashkortostan

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Abstract


Type 2 diabetes mellitus (T2DM) is one of the most acute problems of the modern world. The disease is characterized by high ratio of micro- and macrovascular complications. T2DM is a multifactorial and polygenic disease, structure of hereditary predisposition to which may be population-specific.

Aim — the analysis of allelic associations of adiponectin gene (ADIPOQ, rs17366743) with T2DM, its clinical and metabolic characteristics and complications in T2DM patients resident in the Republic of Bashkortostan.

Material and methods. 3 PCR-based method of genotyping with polymorphic marker rs17366743 of ADIPOQ gene in 433 T2DM patients and 428 healthy controls, residents of Bashkortostan.

Results. The ratio of genotype CT and allele С was higher in T2DM patients compared with controls (15.7% vs. 6.8%; p=0.0002 and 7.8% vs. 3.4%; p<0.0001, respectively). Genotype ТТ and allele Т were less frequent in T2DM than in healthy subjects (84.3 and 93,2%; p=0.0002; 92.2 and 96.6%, p<0.0001, respectively). The association with the development of diabetic retinopathy and cataract was shown (p=0,044, p=0,008, respectively).

Conclusions. Allele C and genotype CT are risk markers of T2DM (OR=2.43 and 2.56 respectively).


Diana S. Avzaletdinova

Bashkir State Medical University

Author for correspondence.
Email: hyppocrat@mail.ru
ORCID iD: 0000-0002-1590-6433
SPIN-code: 5540-6951

Russian Federation, 450008, Ufa, Lenin street, 3

MD, PhD

Liaisan F. Sharipova

Institute of Biochemistry and Genetics of Ufa Scientific Centre of the Russian Academy of Sciences

Email: ecolab_203@mail.ru
ORCID iD: 0000-0003-4866-0983
SPIN-code: 6997-7627

Russian Federation, 71, Oktyabrya Ave., Ufa, Republic of Bashkortostan, 450054

graduate student of the department of endocrinology

Olga V. Kochetova

Institute of Biochemistry and Genetics of Ufa Scientific Centre of the Russian Academy of Sciences

Email: olga_mk78@mail.ru
ORCID iD: 0000-0003-2071-0969
SPIN-code: 3461-3952

Russian Federation, 71, Oktyabrya Ave., Ufa, Republic of Bashkortostan, 450054

PhD

Tatiana V. Morugova

Bashkir State Medical University

Email: tmorugova@yandex.ru
ORCID iD: 0000-0001-7405-486X
SPIN-code: 2976-9605

Russian Federation, 450008, Ufa, Lenin street, 3

MD, PhD, Professor

Olga E. Mustafina

Institute of Biochemistry and Genetics of Ufa Scientific Centre of the Russian Academy of Sciences

Email: anmareg@mail.ru
ORCID iD: 0000-0002-5118-6533
SPIN-code: 5757-8712

Russian Federation, 71, Oktyabrya Ave., Ufa, Republic of Bashkortostan, 450054

PhD, Professor

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Copyright (c) 2019 Avzaletdinova D.S., Sharipova L.F., Kochetova O.V., Morugova T.V., Mustafina O.E.

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