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Mechanisms for the development of arterial hypertension in overweight adolescents and young adults

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Abstract


In recent years, an increase in the number of young people with arterial hypertension (AH) has occurred together with the increased prevalence of obesity. It is generally recognized that obesity plays an important role in the pathogenesis of hypertension in adolescents and young adults. In adolescents of non-European ethnicity with a family history of disease, a low birth weight and sedentary lifestyle, and insufficient physical activity and poor sleep quality, excess weight is accompanied by a high probability of AH. High tolerance to cardio-respiratory exertion and a number of genetic polymorphisms can play a protective role against this pathology. Biochemical studies in young people with hypertension and excess weight display a number of features, including levels of hormones and enzymes of the renin-angiotensin system, associated with lipid metabolism and inflammation. Adolescents with hypertension can be included in the group of young people at high risk of damage to affected organs and the subsequent development of cardiovascular diseases, based on a number of characteristics: blood pressure readings, BMI, age, family history and ethnicity.


Aynur G. Mustafayeva

Azerbaijan Medical University

Author for correspondence.
Email: nauchnayastatya@yandex.ru
ORCID iD: 0000-0001-9647-7839

Azerbaijan, AZE 1022, Baku, street Gasimzade, 14

MD, PhD

  1. Psaltopoulou T, Hatzis G, Papageorgiou N, et al. Socioeconomic status and risk factors for cardiovascular disease: impact of dietary mediators. Hellenic J Cardiol. 2017;58(1):32−42. doi: 10.1016/j.hjc.2017.01.022.
  2. World Health Organization. Interim Report of the Commission on Ending Childhood Obesity. Geneva: Switzerland; 2015 [cited 2015 April 1]. Available from: https://www.who.int/end-childhood-obesity/commission-ending-childhood-obesity-interim-report.pdf.
  3. Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of obesity and trends in body mass index among US children and adolescents, 1999–2010. JAMA. 2012;307(5):483−490. doi: 10.1001/jama.2012.40.
  4. Лузина Е.В., Томина Е.А., Жилина А.А. Ожирение и заболевания органов пищеварения // Клиническая медицина. – 2013. – Т.91. – №6. – С. 63−67. [Luzina EV, Tomina EA, Zhilina AA. Obesity and diseases of digestive organs. Klinicheskaia meditsina. 2013;91(6):63−67 (In Russ.)].
  5. Чернышова Т.Е., Реверчук И.В., Меликян И.А. Стресс как предиктор метаболического синдрома // Личность в экстремальных условиях и кризисных ситуациях жизнедеятельности. – 2013. – №3. – С. 106−109. [Chernyshova TE, Reverchuk IV, Melikjan IA. Stress as a predictor of metabolic syndrome. Lichnost’ v jekstremal’nyh uslovijah i krizisnyh situacijah zhiznedejatel’nosti. 2013;(3):106−109. (In Russ.)].
  6. Антипова С.И., Антипов В.В. Болезни системы кровообращения: эпидемиологические и демографические сопоставления // Медицинские новости. – 2011. – №12. – С. 37−43. [Antipova SI, Antipov VV. Circulation system diseases: epidemiologic and demographic comparison. Medicinskie novosti. 2011;(12):37−43. (In Russ.)].
  7. Din-Dzietham R, Liu Y, Bielo M, Shamsa F. High blood pressure trends in children and adolescents in national surveys, 1963 to 2002. Circulation. 2007;116(13):1488–1496. doi: 10.1161/CIRCULATIONAHA.106.683243.
  8. Koebnick C, Black MH, Wu J, et al. High blood pressure in overweight and obese youth: implications for screening. J Clin Hypertens (Greenwich). 2013;15(11):793−805. doi: 10.1111/jch.12199.
  9. McNiece KL, Poffenbarger T, Turner J, et al. Prevalence of hypertension and pre-hypertension among adolescents. J Pediatr. 2007;150(6):640−4, 644.e1. doi: 10.1016/j.jpeds.2007.01.052.
  10. Lin FH, Chu NF, Hsieh AT. The trend of hypertension and its relationship to the weight status among Taiwanese young adolescents. J Hum Hypertens. 2012;26(1):48−55. doi: 10.1038/jhh.2010.121.
  11. Coatmellec-Taglioni G, Ribière C. Factors that influence the risk of hypertension in obese individuals. Curr Opin Nephrol Hypertens. 2003;12(3):305−308. doi: 10.1097/01.mnh.0000069863.94246.1e.
  12. Дзяк Г.В., Колесник Т.В. Генотипические «ансамбли» полиморфных маркеров генов ренинангиотензивной системы у больных с гипертонической болезнью // Український кардіологічний журнал. – 2008. – №2. – С. 37–43. [Dzjak GV, Kolesnik TV. Genotipicheskie «ansambli» polimorfnyh markerov genov renin-angiotenzivnoi sistemy u bol’nyh s gipertonicheskoi bolezn’ju. Ukr. kardіol. zhurnal. 2008;(2):37–43. (In Russ.)].
  13. Ройтберг Г.Е., Сластникова И.Д., Дорош Ж.В., Дмитриева О.Ю. Влияние физической нагрузки на основные компоненты метаболического синдрома // Профилактическая медицина. – 2016. – Т.19. – №3. – С. 28−33. [Rojtberg GE, Slastnikova ID, Dorosh ZhV, Dmitrieva OJu. Effect of physical exercise on the major components of metabolic syndrome. Profilakticheskaja medicina. 2016;19(3):28−33. (In Russ).] doi: 10.17116/profmed201619328-33.
  14. Guyenet SJ, Schwartz MW. Clinical review: regulation of food intake, energy balance, and body fat mass: implications for the pathogenesis and treatment of obesity. J Clin Endocrinol Metab. 2012;97(3):745−755. doi: 10.1210/jc.2011-2525.
  15. Portela DS, Vieira TO, Matos SM, et al. Maternal obesity, environmental factors, cesarean delivery and breastfeeding as determinants of overweight and obesity in children: results from a cohort. BMC Pregnancy Childbirth. 2015;15:94. doi: 10.1186/s12884-015-0518-z.
  16. Хайбуллина З.Р., Косникова И.В. Проявления метаболического синдрома у больных мультифокальным атеросклерозом // Вестник Новосибирского государственного педагогического университета. – 2014. – №5. – С. 127−136. [Khaybullina ZR, Kosnikova IV. Components of the metabolic syndrome at patients with the multifocal atherosclerosis. Vestnik Novosibirskogo gosudarstvennogo pedagogicheskogo universiteta. 2014;(5):127−136. (In Russ.)]. doi: 10.15293/2226-3365.1405.14.
  17. Matsuzawa Y. Metabolic syndrome – definition and diagnostic criteria in Japan. J Atheroscler Thromb. 2005;12(6):301. doi: 10.5551/jat.12.301.
  18. Kotsis VT, Stabouli SV, Papamichael CM, Zakopoulos NA. Impact of obesity in intima media thickness of carotid arteries. Obesity (Silver Spring). 2006;14(10):1708−1715. doi: 10.1038/oby.2006.196.
  19. Joki N, Hase H, Takahashi Y, et al. Angiographical severity of coronary atherosclerosis predicts death in the first year of hemodialysis. Int Urol Nephrol. 2003;35(2):289−297. doi: 10.1023/b:urol.0000020356.82724.37.
  20. Landsberg L, Krieger DR. Obesity, metabolism, and the sympathetic nervous system. Am J Hypertens. 1989;2(3 Pt 2):125S−132S. doi: 10.1093/ajh/2.3.125s.
  21. Wofford MR, Adair C, Anderson DC, et al. Alpha and beta adrenergic blockade in obese and lean hypertensive subjects. Hypertension. 1998;(32):595.
  22. Serra A, Romero R, Lopez D, et al. Renal injury in the extremely obese patients with normal renal function. Kidney Int. 2008;73(8):947−955. doi: 10.1038/sj.ki.5002796.
  23. Cignarelli M, Lamacchia O. Obesity and kidney disease. Nutr Metab Cardiovasc Dis. 2007;17(10):757−762. doi: 10.1016/j.numecd.2007.03.003.
  24. Gairolla J, Kler R, Modi M, Khurana D. Leptin and adiponectin: pathophysiological role and possible therapeutic target of inflammation in ischemic stroke. Rev Neurosci. 2017;28(3):295−306. doi: 10.1515/revneuro-2016-0055.
  25. Koleva DI, Orbetzova MM, Nikolova JG, Deneva TI. Pathophysiological role of adiponectin, leptin and asymmetric dimethylarginine in the process of atherosclerosis. Folia Med (Plovdiv). 2016;58(4):234−240. doi: 10.1515/folmed-2016-0039.
  26. Obradovic M, Stanimirovic J, Panic A. Regulation of Na+/K+-ATPase by estradiol and IGF-1 in cardio-metabolic diseases. Curr Pharm Des. 2017;23(10):1551−1561. doi: 10.2174/1381612823666170203113455.
  27. Oishi K, Zheng B, Kuo JF. Inhibition of Na, K-ATPase and sodium pump by protein kinase C regulators sphingosine, lysophosphatidylcholine, and oleic acid. J Biol Chem. 1990;265(1):70−75.
  28. Ghomari-Boukhatem H, Bouchouicha A, Mekki K, et al. Blood pressure, dyslipidemia and inflammatory factors are related to body mass index in scholar adolescents. Arch Med Sci. 2017;13(1):46−52. doi: 10.5114/aoms.2017.64713.
  29. Ferrario CM, Schiavone MT. The renin-angiotensin system: Importance in physiology and pathology. Cleve Clin J Med. 1989; 56(4):439−446. doi: 10.3949/ccjm.56.4.439.
  30. Yiannikouris F, Karounos M, Charnigo R, et al. Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic blood pressure in mice. Am J Physiol Regul Integr Comp Physiol. 2012;302(2):R244−251. doi: 10.1152/ajpregu.00323.2011.
  31. Евсиков Е.М., Шарипов Р.А., Обруч В.С., и др. Особенности клинического течения и патогенеза артериальной гипертензии у больных с нарушением толерантности к глюкозе // Российский кардиологический журнал. – 2011. – №5. – С. 17−23. [Evsikov EM, Sharipov RA, Obruch VS, et al. Clinical course and pathogenesis of arterial hypertension in patients with impaired glucose tolerance. Russian Journal of Cardiology. 2011;(5):17−23. (In Russ.)]. doi: 10.15829/1560-4071-2011-5-17-23.
  32. Maser RE, Lenhard MJ. An overview of the effect of weight loss on cardiovascular autonomic function. Curr Diabetes Rev. 2007;3(3):204−211. doi: 10.2174/157339907781368931.
  33. Hannon TS, Gupta S, Li Z, et al. The effect of body mass index on blood pressure varies by race among obese children. J Pediatr Endocrinol Metab. 2015;28(5−6):533−538. doi: 10.1515/jpem-2014-0225.
  34. Harding S, Maynard M, Cruickshank K, Teyhan A. Overweight, obesity and high blood pressure in an ethnically diverse sample of adolescents in Britain: the Medical Research Council DASH study. Int J Obes (Lond). 2008;32(1):82−90. doi: 10.1038/sj.ijo.0803662.
  35. Puri M, Flynn JT, Garcia M, et al. The frequency of elevated blood pressure in obese minority youth. J Clin Hypertens (Greenwich). 2008;10(2):119−124. doi: 10.1111/j.1751-7176.2008.07285.x.
  36. La Manna A, Spagnoletti T, Galizia G, et al. [Statistical analysis of risk factors for hypertension in obese children (Article in Italian)]. Boll Soc Ital Biol Sper. 1982;58(5):253−258.
  37. Siklar Z, Berberoglu M, Savas Erdeve S, et al. Contribution of clinical, metabolic, and genetic factors on hypertension in obese children and adolescents. J Pediatr Endocrinol Metab. 2011;24(1−2):21−24. doi: 10.1515/jpem.2011.105.
  38. Lurbe E, Carvajal E, Torro I, et al. Influence of concurrent obesity and low birth weight on blood pressure phenotype in youth. Hypertension. 2009;53(6):912−917. doi: 10.1161/hypertensionaha.109.129155.
  39. Strufaldi MW, Silva EM, Franco MC, Puccini RF. Blood pressure levels in childhood: probing the relative importance of birth weight and current size. Eur J Pediatr. 2009;168(5):619−624. doi: 10.1007/s00431-008-0813-z.
  40. Shatat IF, Freeman KD, Vuguin PM, et al. Relationship between adiponectin and ambulatory blood pressure in obese adolescents. Pediatr Res. 2009;65(6):691−695. doi: 10.1203/PDR.0b013e31819ea776.
  41. Korek E, Krauss H. Novel adipokines: their potential role in the pathogenesis of obesity and metabolic disorders. Postepy Hig Med Dosw (Online). 2015;69(0):799−810. doi: 10.5604/17322693.1161415.
  42. Tu W, Eckert GJ, DiMeglio LA, et al. Intensified effect of adiposity on blood pressure in overweight and obese children. Hypertension. 2011;58(5):818−824. doi: 10.1161/hypertensionaha.111.175695.
  43. Csabi G, Molnár D, Hartmann G. Urinary sodium excretion: association with hyperinsulinaemia, hypertension and sympathetic nervous system activity in obese and control children. Eur J Pediatr. 1996;155(10):895−897. doi: 10.1007/bf02282841.
  44. Glowinska B, Urban M, Koput A. Cardiovascular risk factors in children with obesity, hypertension and diabetes: lipoprotein(a) levels and body mass index correlate with family history of cardiovascular disease. Eur J Pediatr. 2002;161(10):511−518. doi: 10.1007/s00431-002-1040-7.
  45. Pervanidou P, Akalestos A, Sakka S, et al. Gender dimorphic associations between N-terminal pro-brain natriuretic peptide, body mass index and blood pressure in children and adolescents. Horm Res Paediatr. 2010;73(5):341−348. doi: 10.1159/000308166.
  46. Noronha JA, Medeiros CC, Cardoso Ada S, et al. C-reactive protein and its relation to high blood pressure in overweight or obese children and adolescents [Article in English, Portuguese]. Rev Paul Pediatr. 2013;31(3):331−337. doi: 10.1590/S0103-05822013000300009.

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