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The forearm fractures in patients with diabetes and without diabetes in population sample aged over 50 years (Novosibirsk)

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Abstract


BACKGROUND: The attention to the forearm fractures, as to osteoporotic fractures, is important for ensuring early detection of individuals at increased risk of future fractures and taking preventive measures.

AIMS: To determine the frequency of a history of forearm fractures in patients with type 2 diabetes mellitus (DM2) and without diabetes, and their association with risk factors for chronic non-communicable diseases (NCD).

MATERIAL AND METHODS: In 2015–2017, in Novosibirsk, a random urban population sample of males and females, 58–84 years old (n=3878), was surveyed. The study included persons who signed the informed consent to conduct the study, excluded individuals who wrote a waiver of taking blood to determine biochemical parameters. In total, the analysis included n=3393 people, 718 of them with DM2 (21.2%). Work design is cross-sectional research. The collection of information on fractures during for the last 3 years, the registration of socio-demographic data; and risk factors for NCD, a study of biochemical blood parameters. The analysis of the association of DM2 and a complex of risk factors for NCD with a chance of a forearm fracture.

RESULTS: The prevalence of forearm fractures in the last 3 years did not differ in patients with DM2 compared with those examined without diabetes and was 2.4% and 2.8%, respectively (p=0.557). Men with fractures had higher cholesterol and HDL values, women had lower body mass index (BMI), compared with people without fractures. According to the results of a multivariate analysis in women, the chance of a forearm fracture is directly associated with smoking in the past, a total cholesterol level of more than 200 mg/dl and inversely associated with a BMI. In men, associations were found of the chance of a forearm fracture with an increase in the level of cholesterol. There was no evidence of DM2 with forearm fracture.

CONCLUSION: The obtained data on the incidence of fractures and their association with risk factors for chronic low risk infections suggest the need for preventive measures for osteoporotic fractures, both in people with and without DM2.


Elena S. Mazurenko

Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences; Novosibirsk Research Institute of Traumatology and Orthopaedics n.a. Ya.L. Tsivyan

Author for correspondence.
Email: poltorackayaes@gmail.com
ORCID iD: 0000-0003-3351-1993
SPIN-code: 6027-1764

Russian Federation, 175/1, st. Borisa Bogatkova, Novosibirsk, 630089; 17, st. Frunze, Novosibirsk, 630091

graduate student; endocrinologist 

Sofiya K. Malyutina

Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences

Email: smalyutina@hotmail.com
ORCID iD: 0000-0001-6539-0466
SPIN-code: 6780-9141

Russian Federation, 175/1, st. Borisa Bogatkova, Novosibirsk, 630089  

MD, PhD, Professor

Liliya V. Shcherbakova

Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences

Email: 9584792@mail.ru
ORCID iD: 0000-0001-9270-9188
SPIN-code: 5849-7040

Russian Federation, 175/1, st. Borisa Bogatkova, Novosibirsk, 630089  

senior research associate

Svetlana V. Mustafina

Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences

Email: svetlana3548@gmail.com
ORCID iD: 0000-0003-4716-876X
SPIN-code: 8395-1395

Russian Federation, 175/1, st. Borisa Bogatkova, Novosibirsk, 630089  

MD, PhD

Tatiana M. Nikitenko

Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences

Email: t_nikitenko_72@mail.ru
ORCID iD: 0000-0002-3828-1077
SPIN-code: 4211-5321

Russian Federation, 175/1, st. Borisa Bogatkova, Novosibirsk, 630089 

MD, PhD

Martin Bobak

University College London

Email: m.bobak@ucl.ac.uk
ORCID iD: 0000-0002-2633-6851

United Kingdom, London

Professor of Epidemiology, Epidemiology & Public Health, Institute of Epidemiology & Health Faculty of Pop Health Sciences

Oksana D. Rymar

Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences

Email: orymar23@gmail.com
ORCID iD: 0000-0003-4095-0169
SPIN-code: 8345-9365

Russian Federation, 175/1, st. Borisa Bogatkova, Novosibirsk, 630089 

MD, PhD

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Supplementary files

Supplementary Files Action
1. The frequency of FDD fractures over the past 3 years in individuals with diabetes mellitus and without carbohydrate metabolism disorders. View (11KB) Indexing metadata

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Copyright (c) 2019 Mazurenko E.S., Malyutina S.K., Shcherbakova L.V., Mustafina S.V., Nikitenko T.M., Bobak M., Rymar O.D.

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