Diagnosis of congenital sexual maldevelopment in boys with bilateral inguinal cryptorchidism during minipuberty

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Abstract


BACKGROUND: Cryptorchidism is associated with the risk of infertility and can be a symptom of congenital sexual maldevelopment.

AIM: To assess the functional status of the pituitary gland and sexual glands in boys aged 1–6 months with bilateral inguinal cryptorchidism and to reveal the congenital sexual maldevelopment during minipuberty.

METHODS: Twenty-one boys aged 1–6 months (the minipuberty period) with isolated bilateral inguinal cryptorchidism and 40 healthy boys aged 2–3 months (the control group) were examined. The gonadal status was assessed and serum levels of sex hormones were measured. Molecular genetic testing was performed if there were indications for it.

RESULTS: The results of hormone analysis were used to divide the patients into three groups: group 1 – patients with normal serum levels of gonadotropin and sex hormones; group 2 – patients with elevated gonadotropin level and low levels of anti-Müllerian hormone (AMH) and inhibin B, and group 3 – patients with zero gonadotropin and testosterone levels and low levels of AMH and inhibin B. Group 1 patients had no functional disturbances in the pituitary–gonadal system. Failure of Sertoli cells associated with a high risk of infertility was detected in group 2 patients. Group 3 patients were diagnosed with hypogonadotropic hypogonadism verified by molecular genetic tests.

CONCLUSION: Hormonal testing of patients with bilateral inguinal cryptorchidism during minipuberty makes it possible to early detect the congenital sexual maldevelopment.


Nadezda Y. Raygorodskaya

V.I. Razumovskiy Saratov State Medical University

Author for correspondence.
Email: nraygorodskaya@gmail.com
ORCID iD: 0000-0003-0361-5329
SPIN-code: 4227-4358

Russian Federation, 112, Bolshaya Kazachia street, 410012

MD, PhD

Nina V. Bolotova

V.I. Razumovskiy Saratov State Medical University

Email: kafedranv@mail.ru
ORCID iD: 0000-0002-8148-526X
SPIN-code: 5061-1600

Russian Federation, 112, Bolshaya Kazachia street, 410012

MD, PhD, Professor

Marina L. Chekhonatskaya

V.I. Razumovskiy Saratov State Medical University

Email: fax-1@yandex.ru
ORCID iD: 0000-0002-4056-2951
SPIN-code: 7574-3230

Russian Federation, 112, Bolshaya Kazachia street, 410012

MD, PhD, Professor

Vadim K. Polyakov

V.I. Razumovskiy Saratov State Medical University

Email: polyakov_vk@mail.ru
ORCID iD: 0000-0001-6162-7884
SPIN-code: 9928-9682

Russian Federation, 112, Bolshaya Kazachia street, 410012

MD, PhD

Ludmila N. Sedova

V.I. Razumovskiy Saratov State Medical University

Email: sedovamila-2015@ya.ru
ORCID iD: 0000-0002-4667-8736
SPIN-code: 5387-3439

Russian Federation, 112, Bolshaya Kazachia street, 410012

MD, PhD

Veronika A. Somova

V.I. Razumovskiy Saratov State Medical University

Email: tigronika263pz@rambler.ru

Russian Federation, 112, Bolshaya Kazachia street, 410012

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Copyright (c) 2019 Raygorodskaya N.Y., Bolotova N.V., Chekhonatskaya M.L., Polyakov V.K., Sedova L.N., Somova V.A.

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