Secondary hyperaldosteronism and medullary nephrocalcinosis caused by self-administered and uncontrolled laxative use in an adolescent patient

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Abstract


Secondary hyperaldosteronism is respondent aldosterone secretion increase, occurring due to some diseases or drug use. It may be accompanied by normal arterial pressure with/without water retention or arterial hypertension without water retention. Secondary hyperaldosteronism without arterial hypertension and without water retention is usually caused by the use of laxative and diuretic drugs. This condition is characterized by the lack of salt wasting symptoms, presence of myalgia and muscle weakness resulting from hypokalemia, calcium oxalate crystalluria and sonographic signs of medullary nephrocalcinosis. Such characteristics of water-salt exchange and presence of nephrocalcinosis in combination with hypercalciuria are defined as Bartter-like syndrome. Peculiarity of the given clinical case is determined not by a diagnostic difficulty of secondary hyperaldosteronism but concealment of long term self-administered use of laxatives > 2 years without medical indications in a female patient, resulting in medullary nephrocalcinosis. A well-informed patient may endanger medical practice, because it is impossible to foresee everything including the uncontrolled self-administered drug use leading to the undesirable consequences.


Elena N. Sibileva

Northern State Medical University; Arkhangelsk Children’s Clinical Hospital named after P.G. Vyzhletsov

Author for correspondence.
Email: sibilena@mail.ru
ORCID iD: 0000-0001-5702-6218

Russian Federation, 163000, Arkhangelsk, Troitsky avenue, 51; 7, Obvodnyy kan. ave., Arkhangelsk, 163002

MD, PhD, professor, Department of Pediatrics

Nadezhda Yu. Mironova

Arkhangelsk Children’s Clinical Hospital named after P.G. Vyzhletsov

Email: numir87@gmail.com
ORCID iD: 0000-0003-2393-9099
SPIN-code: 9663-2228

Russian Federation, 7, Obvodnyy kan. ave., Arkhangelsk, 163002

MD

Galina V. Korobitcina

Arkhangelsk Children’s Clinical Hospital named after P.G. Vyzhletsov

Email: galkor75@mail.ru
ORCID iD: 0000-0002-6428-4730
SPIN-code: 9524-2455

Russian Federation, 7, Obvodnyy kan. ave., Arkhangelsk, 163002

MD

Olga T. Koshlakova

Arkhangelsk Children’s Clinical Hospital named after P.G. Vyzhletsov

Email: koshlackowa.olga@yandex.ru
ORCID iD: 0000-0002-3341-984X
SPIN-code: 4071-3980

Russian Federation, 7, Obvodnyy kan. ave., Arkhangelsk, 163002

MD

Olga E. Ipatova

Arkhangelsk Children’s Clinical Hospital named after P.G. Vyzhletsov

Email: ipat-olga@yandex.ru
ORCID iD: 0000-0003-1380-2400

Russian Federation, 7, Obvodnyy kan. ave., Arkhangelsk, 163002

PhD, MD

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Copyright (c) 2019 Sibileva E.N., Mironova N.Y., Korobitcina G.V., Koshlakova O.T., Ipatova O.E.

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