Sustained ventricular tachycardia in a patient with a single ventricle of the heart and a pheochromocytoma
- Authors: Melkozerov K.V.1, Kuznetsov A.B.1, Kalashnikov V.Y.1, Abdulkhabirova F.М.1, Kuznetsov S.N.1, Gorbacheva A.M.1, Dedov I.I.1
- Affiliations:
- Endocrinology Research Centre
- Issue: Vol 65, No 2 (2019)
- Pages: 107-112
- Section: Case Reports
- URL: https://probl-endojournals.ru/probl/article/view/9949
- DOI: https://doi.org/10.14341/probl9949
- Cite item
Abstract
A pheochromocytoma is a rare tumor that develops from adrenomedullary chromaffin cells and produce ones or more catecholamines, including adrenaline, norepinephrine, and dopamine. On rare occasions a pheochromocytoma is hormonally inactive. Cyanotic heart disease is also a relatively rare pathology. One of its least frequently occurring variants is the single ventricle of the heart. Presumably, in patients with cyanotic heart defects, the occurrence of pheochromocytes and paragangliomas will be higher due to the presence of certain germinative and somatic mutations. In cyanotic heart defects, the development of malignant arrythmias is one of the frequent causes of death. A combination of a pheochromocytoma with a single ventricle of the heart is extremely rare: only eight such cases have been described in the literature. This article describes a young patient with a unique case of a single ventricle of the heart, pheochromocytoma and sustained ventricular tachycardia. The cause of the ventricular tachycardia, in all likelihood, was inappropriate medical care – in this case, a prescription for verapamil. The surgical excision of the pheochromocytoma and the referral of the patient for cardiac surgery became possible only after correcting the antihypertensive and antiarrhythmic therapy. Verapamil was replaced with a combination of doxazosin and amiodarone, resulting in relatively satisfactory blood pressure readings and sinus rhythm.

Konstantin V. Melkozerov
Endocrinology Research Centre
Email: melkozerovkv@gmail.com
ORCID iD: 0000-0002-7328-6316
SPIN-code: 5307-9820
Russian Federation, 11 Dm.Ulyanova street, 117036 Moscow, Russia
MD, PhD
Alexander B. Kuznetsov
Endocrinology Research Centre
Email: abkuznetsoff@yandex.ru
ORCID iD: 0000-0002-9008-6893
SPIN-code: 8253-4026
Russian Federation, 11 Dm.Ulyanova street, 117036 Moscow, Russia
MD, PhD
Victor Yu. Kalashnikov
Endocrinology Research Centre
Email: victor9368@gmail.com
ORCID iD: 0000-0001-5573-0754
SPIN-code: 5342-7253
Russian Federation, 11 Dm.Ulyanova street, 117036 Moscow, Russia
MD, PhD, Professor
Fatima М. Abdulkhabirova
Endocrinology Research Centre
Email: a-fatima@yandex.ru
ORCID iD: 0000-0001-8580-2421
SPIN-code: 2462-1115
Russian Federation, 11 Dm.Ulyanova street, 117036 Moscow, Russia
MD, PhD
Sergey N. Kuznetsov
Endocrinology Research Centre
Email: kuznetsov_enc@mail.ru
ORCID iD: 0000-0001-8558-7725
SPIN-code: 9870-2578
Russian Federation, 11 Dm.Ulyanova street, 117036 Moscow, Russia
MD, PhD
Anna M. Gorbacheva
Endocrinology Research Centre
Author for correspondence.
Email: ann.gorbachewa@yandex.ru
ORCID iD: 0000-0003-2669-9457
SPIN-code: 4568-4179
Scopus Author ID: 57190977461
ResearcherId: F-2798-2018
Russian Federation, 11 Dm.Ulyanova street, 117036 Moscow, Russia
MD
Ivan I. Dedov
Endocrinology Research Centre
Email: dedov@endocrincentr.ru
ORCID iD: 0000-0002-8175-7886
SPIN-code: 5873-2280
Russian Federation, 11 Dm.Ulyanova street, 117036 Moscow, Russia
MD, PhD, Professor
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Supplementary files
Supplementary Files | Action | ||
1. | Fig. 1. Electrocardiogram on admission. Monomorphic ventricular tachycardia is recorded. | View (415KB) | Indexing metadata |
2. | Fig. 2. Echocardiography data. | View (145KB) | Indexing metadata |