Perspectives of application of intranasally administered insulin for correction of metabolic and hormonal disorders in diabetes mellitus and metabolic syndrome

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Abstract


In recent years, the possibility of using intranasally administered insulin to treat Alzheimer’s disease and other cognitive disorders has been widely studied. At the same time, the possibility of its use in the treatment of diabetes mellitus is practically not investigated, which is due to the insufficient study of the molecular mechanisms of its action on the hormonal and metabolic status of the organism. The review discusses literature data and the results of our own research on the role of insulin in the central regulation of energy homeostasis, as well as on the experience of using intranasally administered insulin to correct eating disorders and metabolic and hormonal dysfunctions developing under conditions of experimental diabetes mellitus and metabolic syndrome. In studies involving healthy volunteers, various effects of intranasally administered insulin were shown, including effects on cognitive function, eating behavior and weight loss, and the gender specificity of its action was found. In the course of numerous studies of intranasally administered insulin in animal models of diabetes mellitus, not only stabilization of carbohydrate homeostasis was shown, but also a positive effect in the form of restoration of the functional activity of insulin signaling pathways in the hypothalamus and other parts of the brain. We have presented and analyzed data on the systemic effects of intranasally administered insulin in rodents with experimental models of diabetes mellitus, as well as in healthy individuals.


Alexander O. Shpakov

Sechenov Institute of Evolutionary Physiology and Biochemistry of Russian Academy of Sciences

Email: alex_shpakov@list.ru
ORCID iD: 0000-0002-4293-3162
SPIN-code: 6335-8311
Scopus Author ID: 35231150500

Russian Federation, 44, Thorez prospekt, St.-Petersburg, 194223

PhD

Kira V. Derkach

Sechenov Institute of Evolutionary Physiology and Biochemistry of Russian Academy of Sciences

Email: derkatch_kira@list.ru
ORCID iD: 0000-0001-6555-9540
SPIN-code: 6925-1558
Scopus Author ID: 6603743572

Russian Federation, 44, Thorez prospekt, St.-Petersburg, 194223

PhD

Elena V. Surkova

Endocrinology Research Centre

Email: elenasurkova@mail.ru
ORCID iD: 0000-0002-3973-7638
SPIN-code: 7944-3869
Scopus Author ID: 6602194740

Russian Federation, 11, Dm. Ulyanova street, Moscow, 117036

MD, PhD

Alexey I. Bespalov

Endocrinology Research Centre

Author for correspondence.
Email: finger1ess@mail.ru
ORCID iD: 0000-0003-1584-5690
SPIN-code: 9466-2528

Russian Federation, 11, Dm. Ulyanova street, Moscow, 117036

MD

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