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Vol 48, No 6 (2002)

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Children’s health under the conditions of goiter endemia in Yaroslavl
Shubina Y.V., Chernaya N.L., Aleksandrov Y.K., Mozzhukhina L.I.

A comprehensive examination (study of the specific features of health, adaptive processes, and the thyroid status) was made in 159 children aged 8-12 years who lived in areas exposed to a combination of geochemical and man-made environmental factors. The schoolchildren with endemic thyroid enlargement were found to show a higher prevalence of chronic somatic diseases, abnormalities in physical development, and a significant strain of adaptive processes. The epidemiological features of goiter endemia point to the complicated pathogenesis of thyromegaly in children upon combined exposure to man-made and geochemical factors, which is caused not only by iodine deficiency, but also by additional antithyroid factors. This shows it necessary to apply a comprehensive approach to implementing preventive antigoiter measures not only to eliminate iodine deficiency, but also to correct additional strumogenic exposures existing in the region.

Problems of Endocrinology. 2002;48(6):3-7
Clinical endocrinology
Salt iodination is an effective way of liquidation of iodine-deficient diseases in Russia
Gerasimov G.A.

The article is devoted to the salt iodination is an effective way of liquidation of iodine-deficient diseases in Russia.

Problems of Endocrinology. 2002;48(6):7-10
Neonatal iodine provision under the conditions of natural goiter endemia
Taranushenko T.Y., Shcheplyagina L.A., Trifonova I.Y.

Dietary iodine intake values in early neonatality were studied. The actual iodine intake with maternal colostrum averaged 5.1±0.3 µg/day (the recommended daily dietary iodine allowance being 8.3±0.1 µg/day). The calculated neonatal iodine provision value (61.7%) estimated as an actual and recommended dietary iodine intake ratio was additional evidence for low iodine provision in early neonatality. The daily collostrial iodine intake may be regarded as adequate only in 7.7% of the neonatal infants, in 92.3% of the examinees, iodine intake was insufficient. The degree of decreased iodine intake was varying; an important point is that in 28.8% of the neonates, the daily amount of ingested iodine was less than 50% of the recommended allowance.

Problems of Endocrinology. 2002;48(6):10-13
Monitoring of the iodine deficiency program in West Siberia
Suplotova L.A., Sharofilova N.V., Nekrasova M.R., Gubina V.V., Luzina I.G., Kretinina L.N., Osadchenko G.A., Khramova Y.B., Turovinina Y.F.

The article is devoted to the monitoring of the iodine deficiency program in West Siberia.

Problems of Endocrinology. 2002;48(6):13-16
Clinical picture, diagnosis, and treatment of autoimmune thyroiditis
Petunina N.A.

The article is devoted to the clinical picture, diagnosis, and treatment of autoimmune thyroiditis.

Problems of Endocrinology. 2002;48(6):16-21
The pathogenesis, diagnosis, and prediction of postpartum thyroiditis
Krikheli I.O., Potin V.V., Tkachenko N.N., Pigina T.V.

The article is devoted to the pathogenesis, diagnosis, and prediction of postpartum thyroiditis.

Problems of Endocrinology. 2002;48(6):21-26
Secondary hypothyroidism: specific features of diagnosis and treatment
Nagayeva Y.V., Bezlepkina O.B., Goncharov N.P., Kolesnikova G.S., Peterkova V.A.

The article is devoted to the secondary hypothyroidism: specific features of diagnosis and treatment.

Problems of Endocrinology. 2002;48(6):26-30
Evaluation of the growth-regulating system and use the recombinant growth hormone (genotropin) in children with rheumatic diseases and growth impairments on long-term glucocorticosteroid therapy
Sharova A.A., Volevodz N.N., Peterkova V.A.

The paper presents the results of an investigation of the growth - regulating system (STH - insulin-like growth factor 1 - peripheral tissues) in 39 children with rheumatic diseases on longterm continuous glucocorticosteroid therapy. Of them, 6 patients received recombinant growth hormone (R-GH) (Genotropin) for correction of steroidal growth retardation. Twelve-month r-GH therapy made it possible not only to accelerate growth rates, but contributed to diminished manifestations of drug-induced hypercorticism without exerting a significant impact in the course of the underlying disease.

Problems of Endocrinology. 2002;48(6):30-35
For practitioners
Capacities of correction of immunological disorders in hypercorticism (a lecture)
Dedov I.I., Marova Y.I., Belchenko L.V., Manovitskaya A.V.

The article is devoted to the capacities of correction of immunological disorders in hypercorticism.

Problems of Endocrinology. 2002;48(6):35-38
Case Reports
Recurrent pheochromocytoma in a female patient with type IIa multiple endocrine neoplasia
Kuznetsov N.S., Beltsevich D.G., Kuratev L.V., Lysenko M.A., Smorshchok V.N.

The article is devoted to recurrent pheochromocytoma in a female patient with type IIa multiple endocrine neoplasia

Problems of Endocrinology. 2002;48(6):38-39
Thyroid hemigenesia description of three cases
Malievsky O.A.

The article is devoted to the thyroid hemigenesia description of three cases.

Problems of Endocrinology. 2002;48(6):39-40
Use of xenical in the treatment of obesity
Klochkova Y.V.

The article is devoted to use of xenical in the treatment of obesity.

Problems of Endocrinology. 2002;48(6):40-41
Experimental endocrinology
Impact of anxiogenic stress on glucocorticoid sensitivity, glucose tolerance, and alloxan resistance in rats
Volchegorsky I.A., Tseilikman V.E., Ship S.A., Bubnov N.V., Sinitsky A.I.

Four episodes of immobilization stress caused anxiogenic behavioral disorders accompanied by a decrease in sensitivity to glucocorticoid hormones, by an increase in the activity of monoaminooxidase (MAO-B) in the brain tissue, an enhancement in glucose load tolerance, and a reduction in acute hypoxia tolerance in rats. Alloxan-induced diabetes was also associated with a reduction of rat behavioral activity in the open field along with an increase in the cerebral activity of MAO-B. Prior anxiogenic stress potentiated an alloxan-induced increase in cerebral MAO- B activity, enhanced concomitant behavioral disorders in rats, and increased the hyperglycemic effect of alloxan.

Problems of Endocrinology. 2002;48(6):41-44
Role of apolipoprotein A-I in the anabolic effect of steroid hormones
Panin L.Y., Khoshchenko O.M., Usynin I.F.

As early shown, a portion of steroid hormones binds to blood lipoproteins, primarily to high-density lipoproteins (HDL) [Panin et al. 1988]. Steroid hormones together with HDL are captured by resident macrophages of the liver where in secondary lysosomes HDL are degraded to form apoA-I and steroid hormones restore a ∆4, 3-keto group with the participation of 5-α and 5β- reductases to give rise to tetrahydro compounds. In this study, an attempt was undertaken to show a role of a complex of some steroid hormones with apo A-I in realization of the anabolic action of these steroid hormones by using the cultured hepatocytes and concurrently cultured hepatocytes and Kupffer’s cells isolated from the liver of male Wistar rats weighing 180-200 g.

Steroid hormones having an anabolic action, such as androsterone, dehydroepiandrosterone, dehydroepiandrosterone sulfate and tetrahydrocortisol as ingredients of a complex with apolipoprotein A-I (apoA-I), increased the rate of protein biosynthesis and dehydroepiandrosterone sulfate and tetrahydrocortisol also did the rate of DNA synthesis in the cultured hepatocytes. All the hormones had a restored ∆4,3-keto group in the A ring structure. Restoration of this group of steroid hormones and formation of their complex with apoA-I are associated with the action of resident macrophages (Kupffer’s cells). That is the reason that addition of HDL (a source of apoA-I) and cortisol (a source of the restored form - tetrahydrocortisol) to the coculture of hepatocytes and macrophages, by concurrently stimulating the latter by lipopolysaccharide led to a significant increase in the rate of protein and DNA biosynthesis. The findings show an important role of a ∆4,3-keto group of the A ring of steroid hormones and their complex with apo A-I in realizing the anabolic action of steroids.

Problems of Endocrinology. 2002;48(6):45-48
The effects of coordination zinc compound on glucose uptake and the activity of tissue pyruvate dehydrogenase in rats with experimental diabetes mellitus
Samigzhonov A.A., Ergasheva M.Z., Saatov T.S.

Zinc compounds were examined for their effects on the transport of glucose through the membrane and on the activity of pyruvate dehydrogenase of mitochondria of the hearts and skeletal muscles from rats with experimental diabetes mellitus. The objects of the investigations were the rat diaphragm, cardiac and skeletal muscle mitochondria.

The aim of the investigation was to study the effect of the coordination zinc compound piracine on the transport of glucose in the diaphragm and on the activity of pyruvate dehydrogenase of the hearts and skeletal muscles from rats with experimental diabetes mellitus.

Experimental diabetes mellitus was induced by intraperitoneal alloxan hydrate during fasting.

The investigation established that piracine exerted a stimulating effect on glucose transport in experimental diabetes. With the coordination zinc compound, there was an increase in the activity of pyruvate dehydrogenase, which is lowered in diabetes.

The findings provide again evidence for the role of zinc ions in glucose transport and oxidation.

Problems of Endocrinology. 2002;48(6):48-50
Neuroendocrine mechanisms responsible for experimental anovulation of hyperandrogenie origin
Reznikov A.G., Sinitsyn P.V., Tarasenko L.V., Polyakova L.I.

An experimental model of anovulatory infertility of hyperandrogenic origin (subcutaneous implantation of silastic capsules with testosterone to mature female rats) was used to study morphological, hormonal, and biochemical indices that characterize the hypothalamic-pituitary-ovarian system. Disorders found in the functional metabolism of androgens in the hypothalamus, decreased pituitary response to hypothalamic hormone (HH), changes in the pattern of estrous cycles, ovarian morphological changes suggest that there are neuroendocrine disturbances ovulation regulation. The use of flutamide as a drug of experimental antiandrogenic therapy led to a partial normalization of hormonal, biochemical, and morphological characteristics and to recovery of fertility in female rats with anovulatory fertility.

Problems of Endocrinology. 2002;48(6):50-53
Thyroid diseases (Book Review)
Kalinin A.P.

The article is devoted to the Thyroid diseases.

Problems of Endocrinology. 2002;48(6):53-54

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